Aqueous extraction from dachengqi formula granules reduces the severity of mouse acute pancreatitis via inhibition of pancreatic pro-inflammatory signalling pathways

Dachengqi decoction (DCQD) belongs to a family of purgative herbal formulas widely used in China for the treatment of acute pancreatitis (AP). AP is a prevalent digestive disease currently without an effective pharmacological intervention. Formula granules have become the preferred method for delive...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 257; no. NA; p. 112861
Main Authors:	Ma, Xiaohua, Jin, Tao, Han, Chenxia, Shi, Na, Liang, Ge, Wen, Yongjian, Yang, Jingyu, Fu, Xianghui, Lan, Tian, Jiang, Kun, Nunes, Quentin M., Chvanov, Michael, Criddle, David N., Philips, Anthony R., Deng, Lihui, Liu, Tingting, Windsor, John A., Sutton, Robert, Du, Dan, Huang, Wei, Xia, Qing
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 15.07.2020
Subjects:	acinar cells Acinar Cells - drug effects Acinar Cells - metabolism Acinar Cells - pathology Acute pancreatitis Animals anthraquinones Anti-Inflammatory Agents - pharmacology apoptosis Apoptosis - drug effects Aqueous extraction caspase-3 chemical composition China chloroform Chloroform - chemistry Dachengqi formula granules Disease Models, Animal disease severity Experimental models flavonoids fluorescence fluorescence microscopy glycosides granules histopathology honokiol Inflammation Mediators intraperitoneal injection lungs Male messenger RNA mice Mice, Inbred C57BL myeloperoxidase necroptosis Necrosis Pancreas, Exocrine - drug effects Pancreas, Exocrine - metabolism Pancreas, Exocrine - pathology pancreatitis Pancreatitis - metabolism Pancreatitis - pathology Pancreatitis - prevention & control Plant Extracts - pharmacology polyphenols Pro-inflammatory signalling pathways propidium proteins Signal Transduction Solvents - chemistry traditional medicine Water - chemistry China Rhein DMSO Aqueous extraction Experimental models Honokiol DCQD MPO TLCS DFGs NF-κB Acute pancreatitis RT-qPCR CE IL AE MAPK Dachengqi formula granules AP CER TNF-α Pro-inflammatory signalling pathways PI BPI TLR4 Narigeinine TCM
ISSN:	0378-8741, 1872-7573, 1872-7573
Online Access:	Get full text
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