A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells

A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent prob...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 51; no. 31; pp. 6781 - 6784
Main Authors: Hou, Ji-Ting, Li, Kun, Yang, Jin, Yu, Kang-Kang, Liao, Ye-Xin, Ran, Yu-Zhao, Liu, Yan-Hong, Zhou, Xue-Dong, Yu, Xiao-Qi
Format: Journal Article
Language:English
Published: CAMBRIDGE Royal Soc Chemistry 21.04.2015
Subjects:
Animals
Cell Line
Chemistry
Chemistry, Multidisciplinary
Coumarins - chemistry
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - chemistry
Hypochlorous Acid - metabolism
Mice
Mitochondria - metabolism
Physical Sciences
Rhodamines - chemistry
Science & Technology
TURN-ON
ANIMALS
OXIDATIVE STRESS
MYELOPEROXIDASE
ACID
DYES
INFLAMMATION
BODIPY-BASED PROBE
LIVING CELLS
HCLO
ISSN:1359-7345, 1364-548X, 1364-548X
Online Access:Get more information
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Summary:A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO-.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc01217a