A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells

A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent prob...

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Veröffentlicht in:Chemical communications (Cambridge, England) Jg. 51; H. 31; S. 6781 - 6784
Hauptverfasser: Hou, Ji-Ting, Li, Kun, Yang, Jin, Yu, Kang-Kang, Liao, Ye-Xin, Ran, Yu-Zhao, Liu, Yan-Hong, Zhou, Xue-Dong, Yu, Xiao-Qi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: CAMBRIDGE Royal Soc Chemistry 21.04.2015
Schlagworte:
Animals
Cell Line
Chemistry
Chemistry, Multidisciplinary
Coumarins - chemistry
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - chemistry
Hypochlorous Acid - metabolism
Mice
Mitochondria - metabolism
Physical Sciences
Rhodamines - chemistry
Science & Technology
TURN-ON
ANIMALS
OXIDATIVE STRESS
MYELOPEROXIDASE
ACID
DYES
INFLAMMATION
BODIPY-BASED PROBE
LIVING CELLS
HCLO
ISSN:1359-7345, 1364-548X, 1364-548X
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Abstract A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO-.
AbstractList A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO-.
A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO(-).
A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO(-).A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO(-).
Author Zhou, Xue-Dong
Yu, Xiao-Qi
Li, Kun
Yang, Jin
Liao, Ye-Xin
Ran, Yu-Zhao
Yu, Kang-Kang
Hou, Ji-Ting
Liu, Yan-Hong
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  orcidid: 0000-0002-9600-8941
  surname: Hou
  fullname: Hou, Ji-Ting
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 2
  givenname: Kun
  orcidid: 0000-0002-8788-1036
  surname: Li
  fullname: Li, Kun
  email: kli@scu.edu.cn
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 3
  givenname: Jin
  surname: Yang
  fullname: Yang, Jin
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 4
  givenname: Kang-Kang
  orcidid: 0000-0001-5352-1959
  surname: Yu
  fullname: Yu, Kang-Kang
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 5
  givenname: Ye-Xin
  surname: Liao
  fullname: Liao, Ye-Xin
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 6
  givenname: Yu-Zhao
  surname: Ran
  fullname: Ran, Yu-Zhao
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 7
  givenname: Yan-Hong
  surname: Liu
  fullname: Liu, Yan-Hong
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
– sequence: 8
  givenname: Xue-Dong
  orcidid: 0000-0002-9319-7302
  surname: Zhou
  fullname: Zhou, Xue-Dong
  email: zhouxd@scu.edu.cn
  organization: Sichuan Univ, State Key Lab Oral Dis, Chengdu 610041, Sichuan Provinc, Peoples R China
– sequence: 9
  givenname: Xiao-Qi
  surname: Yu
  fullname: Yu, Xiao-Qi
  email: xqyu@scu.edu.cn
  organization: Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan Provinc, Peoples R China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25785927$$D View this record in MEDLINE/PubMed
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Issue 31
Keywords TURN-ON
ANIMALS
OXIDATIVE STRESS
MYELOPEROXIDASE
ACID
DYES
INFLAMMATION
BODIPY-BASED PROBE
LIVING CELLS
HCLO
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Snippet A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response...
A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5...
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SubjectTerms Animals
Cell Line
Chemistry
Chemistry, Multidisciplinary
Coumarins - chemistry
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - chemistry
Hypochlorous Acid - metabolism
Mice
Mitochondria - metabolism
Physical Sciences
Rhodamines - chemistry
Science & Technology
Title A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells
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