Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loc...

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Vydané v:	Nature genetics Ročník 55; číslo 2; s. 198 - 208
Hlavní autori:	Demontis, Ditte, Walters, G. Bragi, Athanasiadis, Georgios, Walters, Raymond, Therrien, Karen, Nielsen, Trine Tollerup, Farajzadeh, Leila, Voloudakis, Georgios, Bendl, Jaroslav, Zeng, Biau, Zhang, Wen, Grove, Jakob, Als, Thomas D., Duan, Jinjie, Satterstrom, F. Kyle, Bybjerg-Grauholm, Jonas, Bækved-Hansen, Marie, Gudmundsson, Olafur O., Magnusson, Sigurdur H., Baldursson, Gisli, Davidsdottir, Katrin, Haraldsdottir, Gyda S., Agerbo, Esben, Hoffman, Gabriel E., Dalsgaard, Søren, Martin, Joanna, Ribasés, Marta, Boomsma, Dorret I., Soler Artigas, Maria, Roth Mota, Nina, Howrigan, Daniel, Medland, Sarah E., Zayats, Tetyana, Rajagopal, Veera M., Nordentoft, Merete, Mors, Ole, Hougaard, David M., Mortensen, Preben Bo, Daly, Mark J., Faraone, Stephen V., Stefansson, Hreinn, Roussos, Panos, Franke, Barbara, Werge, Thomas, Neale, Benjamin M., Stefansson, Kari, Børglum, Anders D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.02.2023 Nature Publishing Group
Predmet:	45/23 45/43 631/208/205/2138 692/699/476/1311 Agriculture Animal Genetics and Genomics Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Biomedical and Life Sciences Biomedicine Bivariate analysis Brain Cancer Research Chromosomes Cognition Cognition & reasoning Cognitive ability Dopamine receptors Gene expression Gene Function Genes Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genomics Human Genetics Humans Hyperactivity Mental disorders Mesencephalon Meta-analysis Neurodevelopmental disorders Risk
ISSN:	1061-4036, 1546-1718, 1546-1718
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