CD74-NRG1 fusions in lung adenocarcinoma

We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional fusion-positive tumors, all of which were of the invasive mucinous s...

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Veröffentlicht in:	Cancer discovery Jg. 4; H. 4; S. 415
Hauptverfasser:	Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Daßler, Juliane, Malchers, Florian, Schöttle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T, Wright, Gavin M, Russell, Prudence A, Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brambilla, Christian G, Lantuejoul, Sylvie, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Heuckmann, Johannes M, Stoelben, Erich, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Muscarella, Lucia A, la Torre, Annamaria, Fazio, Vito M, Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C, Buettner, Reinhard, Zander, Thomas, Wolf, Jürgen, Perner, Sven, Ansén, Sascha, Haas, Stefan A, Yatabe, Yasushi, Thomas, Roman K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2014
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - pathology Adult Aged Aged, 80 and over Animals Antigens, Differentiation, B-Lymphocyte - genetics Base Sequence Cell Line, Tumor Female Gene Expression Profiling Histocompatibility Antigens Class II - genetics Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Male Mice Middle Aged Molecular Sequence Data Neuregulin-1 - genetics NIH 3T3 Cells Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Sequence Analysis, DNA Signal Transduction - genetics
ISSN:	2159-8290, 2159-8290
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