Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial pathway

Carnosic acid (CA), an important bioactive phenolic diterpene mainly found in labiate plants, exerts various biological functions, including antioxidant, anti-inflammatory, antitumor, and neuroprotective activities. In the present study, we proved the deleterious effects of CA against hepatocellular...

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Bibliographic Details
Published in:	Chemico-biological interactions Vol. 277; pp. 91 - 100
Main Authors:	Zhang, Xinrui, Chen, Yiling, Cai, Guangsheng, Li, Xin, Wang, Di
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01.11.2017
Subjects:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carnosic acid (CA) Diterpenes, Abietane - pharmacology Diterpenes, Abietane - therapeutic use Hep G2 Cells Hepatocellular carcinoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice, Inbred BALB C Mitochondria Mitochondria - drug effects Mitochondria - pathology Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Bcl-2 DMSO Hepatocellular carcinoma PARP Carnosic acid (CA) MTT RIPA NF-κB DMEM BSA Mitochondria ANOVA FBS mTOR Apaf-1 CA PBS Reactive oxygen species (ROS) HCC IL-2 H&E staining PVDF MMP NAC DCFH-DA PMSF ROS PI MPTP GAPDH Apoptosis JC-1
ISSN:	0009-2797, 1872-7786, 1872-7786
Online Access:	Get full text
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