Simvastatin in traumatic brain injury: effect on brain edema mechanisms

Traumatic brain injury causes deleterious brain edema, leading to high mortality and morbidity. Brain edema exacerbates neurologic deficits and may be attributable to the breakdown of endothelial cell junction protein, leukocyte infiltration, and matrix metalloproteinase activation. These all contri...

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Bibliographic Details
Published in:	Critical care medicine Vol. 39; no. 10; p. 2300
Main Authors:	Béziaud, Tiphaine, Ru Chen, Xiao, El Shafey, Nelly, Fréchou, Magalie, Teng, Fei, Palmier, Bruno, Beray-Berthat, Virginie, Soustrat, Mathieu, Margaill, Isabelle, Plotkine, Michel, Marchand-Leroux, Catherine, Besson, Valérie C
Format:	Journal Article
Language:	English
Published:	United States 01.10.2011
Subjects:	Animals Antigens, CD - biosynthesis Blood-Brain Barrier - metabolism Brain Edema - drug therapy Brain Edema - etiology Brain Edema - pathology Brain Injuries - complications Cadherins - biosynthesis Claudin-5 Endothelial Cells - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Intercellular Adhesion Molecule-1 - biosynthesis Male Matrix Metalloproteinase 9 - biosynthesis Membrane Proteins - biosynthesis Neutrophils - drug effects Neutrophils - pathology Rats Rats, Sprague-Dawley Simvastatin - pharmacology
ISSN:	1530-0293, 1530-0293
Online Access:	Get more information
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