Parkinson disease

Parkinson disease (PD) is the most common neurodegenerative movement disorder. In Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 000 and 11–19/100 000 per year, respectively. Risk factors include age, male gender and some environmental factors. The aetiology...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	European journal of neurology Ročník 27; číslo 1; s. 27 - 42
Hlavní autoři:	Balestrino, R., Schapira, A.H.V.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England John Wiley & Sons, Inc 01.01.2020
Témata:	Akinesia Brain diseases clinical Diagnosis Differential diagnosis Dopamine receptors Environmental factors Europe Genetics Humans Incidence Inclusion bodies Inclusions Lewy bodies Motor task performance Movement disorders neurodegeneration Neurodegenerative diseases Parkinson disease Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson Disease - etiology Parkinson Disease - therapy Parkinson's disease Pathogenesis pathophysiology Prevalence Rigidity Risk analysis Risk Factors Signs and symptoms Substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology Synuclein treatment Tremor Europe treatment clinical genetics pathophysiology Parkinson disease neurodegeneration movement disorders
ISSN:	1351-5101, 1468-1331, 1468-1331
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Parkinson disease (PD) is the most common neurodegenerative movement disorder. In Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 000 and 11–19/100 000 per year, respectively. Risk factors include age, male gender and some environmental factors. The aetiology of the disease in most patients is unknown, but different genetic causes have been identified. Although familial forms of PD account for only 5%–15% of cases, studies on these families provided interesting insight on the genetics and the pathogenesis of the disease allowing the identification of genes implicated in its pathogenesis and offering critical insights into the mechanisms of disease. The cardinal motor symptoms of PD are tremor, rigidity, bradykinesia/akinesia and postural instability, but the clinical picture includes other motor and non‐motor symptoms. Its diagnosis is principally clinical, although specific investigations can help the differential diagnosis from other forms of parkinsonism. Pathologically, PD is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by accumulation of misfolded α‐synuclein, which is found in intra‐cytoplasmic inclusions called Lewy bodies. Currently available treatments offer good control of motor symptoms but do not modify the evolution of the disease. This article is intended to provide a comprehensive, general and practical review of PD for the general neurologist.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1351-5101 1468-1331 1468-1331
DOI:	10.1111/ene.14108