Parkinson disease

Parkinson disease (PD) is the most common neurodegenerative movement disorder. In Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 000 and 11–19/100 000 per year, respectively. Risk factors include age, male gender and some environmental factors. The aetiology...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of neurology Jg. 27; H. 1; S. 27 - 42
Hauptverfasser: Balestrino, R., Schapira, A.H.V.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England John Wiley & Sons, Inc 01.01.2020
Schlagworte:
Akinesia
Brain diseases
clinical
Diagnosis
Differential diagnosis
Dopamine receptors
Environmental factors
Europe
Genetics
Humans
Incidence
Inclusion bodies
Inclusions
Lewy bodies
Motor task performance
Movement disorders
neurodegeneration
Neurodegenerative diseases
Parkinson disease
Parkinson Disease - diagnosis
Parkinson Disease - epidemiology
Parkinson Disease - etiology
Parkinson Disease - therapy
Parkinson's disease
Pathogenesis
pathophysiology
Prevalence
Rigidity
Risk analysis
Risk Factors
Signs and symptoms
Substantia nigra
Substantia Nigra - metabolism
Substantia Nigra - pathology
Synuclein
treatment
Tremor
Europe
treatment
clinical
genetics
pathophysiology
Parkinson disease
neurodegeneration
movement disorders
ISSN:1351-5101, 1468-1331, 1468-1331
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Parkinson disease (PD) is the most common neurodegenerative movement disorder. In Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 000 and 11–19/100 000 per year, respectively. Risk factors include age, male gender and some environmental factors. The aetiology of the disease in most patients is unknown, but different genetic causes have been identified. Although familial forms of PD account for only 5%–15% of cases, studies on these families provided interesting insight on the genetics and the pathogenesis of the disease allowing the identification of genes implicated in its pathogenesis and offering critical insights into the mechanisms of disease. The cardinal motor symptoms of PD are tremor, rigidity, bradykinesia/akinesia and postural instability, but the clinical picture includes other motor and non‐motor symptoms. Its diagnosis is principally clinical, although specific investigations can help the differential diagnosis from other forms of parkinsonism. Pathologically, PD is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by accumulation of misfolded α‐synuclein, which is found in intra‐cytoplasmic inclusions called Lewy bodies. Currently available treatments offer good control of motor symptoms but do not modify the evolution of the disease. This article is intended to provide a comprehensive, general and practical review of PD for the general neurologist.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1351-5101
1468-1331
1468-1331
DOI:10.1111/ene.14108