Whole‐exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets

Oral mucosal melanoma (OMM) is a rare and aggressive subtype of melanoma with little known about its pathogenesis or carcinogenesis. We therefore performed whole‐exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight into potential genetic drivers of tumor formation. Fo...

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Vydáno v:	The Journal of pathology Ročník 244; číslo 3; s. 358 - 366
Hlavní autoři:	Lyu, Jiong, Song, Zhijian, Chen, Jianhua, Shepard, Matthew J, Song, Hao, Ren, Guoxin, Li, Zhiqiang, Guo, Wei, Zhuang, Zhengping, Shi, Yongyong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Chichester, UK John Wiley & Sons, Ltd 01.03.2018 Wiley Subscription Services, Inc
Témata:	Carcinogenesis Copy number Cyclin-dependent kinase 4 Genetic analysis Melanoma Metastases Mucosa Mutation mutational profile oral cancer oral mucosal melanoma Pigmentation Remission Signal transduction targeted therapy whole‐exome sequencing United Kingdom > UK Ireland oral mucosal melanoma targeted therapy melanoma whole-exome sequencing oral cancer mutational profile
ISSN:	0022-3417, 1096-9896, 1096-9896
On-line přístup:	Získat plný text
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