The intricate anatomy of the periodontal ligament and its development: Lessons for periodontal regeneration

The periodontal ligament (PDL) connects the tooth root and alveolar bone. It is an aligned fibrous network that is interposed between, and anchored to, both mineralized surfaces. Periodontal disease is common and reduces the ability of the PDL to act as a shock absorber, a barrier for pathogens and...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Journal of periodontal research Ročník 52; číslo 6; s. 965 - 974
Hlavní autori: Jong, T., Bakker, A. D., Everts, V., Smit, T. H.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley Subscription Services, Inc 01.12.2017
Predmet:
Alveolar bone
Alveolar Process - anatomy & histology
Anatomy
Animals
biomaterial
Biomedical materials
Functional morphology
Growth factors
Guided Tissue Regeneration, Periodontal - methods
Humans
Hydrogels
Mastication
Mechanical loading
Mechanical properties
Odontogenesis
periodontal attachment
Periodontal ligament
Periodontal Ligament - anatomy & histology
Periodontal Ligament - growth & development
Periodontal Ligament - ultrastructure
Regeneration
stem cells
Teeth
Tissue engineering
Tooth Root - anatomy & histology
periodontal attachment
stem cells
periodontal ligament
tissue engineering
biomaterial
ISSN:0022-3484, 1600-0765, 1600-0765
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The periodontal ligament (PDL) connects the tooth root and alveolar bone. It is an aligned fibrous network that is interposed between, and anchored to, both mineralized surfaces. Periodontal disease is common and reduces the ability of the PDL to act as a shock absorber, a barrier for pathogens and a sensor of mastication. Although disease progression can be stopped, current therapies do not primarily focus on tissue regeneration. Functional regeneration of PDL may be achieved using innovative techniques, such as tissue engineering. However, the complex fibrillar architecture of the PDL, essential to withstand high forces, makes PDL tissue engineering very challenging. This challenge may be met by studying PDL anatomy and development. Understanding PDL anatomy, development and maintenance provides clues regarding the specific events that need to be mimicked for the formation of this intricate tissue. Owing to the specific composition of the PDL, which develops by self‐organization, a different approach than the typical combination of biomaterials, growth factors and regenerative cells is necessary for functional PDL engineering. Most specifically, the architecture of the new PDL to be formed does not need to be dictated by textured biomaterials but can emerge from the local mechanical loading conditions. Elastic hydrogels are optimal to fill the space properly between tooth and bone, may house cells and growth factors to enhance regeneration and allow self‐optimization by the alignment to local stresses. We suggest that cells and materials should be placed in a proper mechanical environment to initiate a process of self‐organization resulting in a functional architecture of the PDL.
Bibliografia:Funding information
This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0022-3484
1600-0765
1600-0765
DOI:10.1111/jre.12477