Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives

Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of mTOR signaling using specific pharmacologi...

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Bibliographic Details
Published in:Journal of cellular physiology Vol. 233; no. 6; pp. 4783 - 4790
Main Authors: Soltani, Arash, Bahreyni, Amirhossein, Boroumand, Nadia, Roshan, Mostafa karimi, Khazaei, Majid, Ryzhikov, Mikhail, Soleimanpour, Saman, Avan, Amir, Hassanian, Seyed Mahdi
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.06.2018
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Arteriosclerosis
Arthritis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - enzymology
Arthritis, Rheumatoid - immunology
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - enzymology
Atherosclerosis - immunology
Cancer
Energy metabolism
Humans
inflamatory diseases
inflammation
Inflammation - drug therapy
Inflammation - enzymology
Inflammation - immunology
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Inflammatory diseases
Inhibitor drugs
Inhibitors
mammalian target of rapamycin
Metabolism
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - immunology
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - enzymology
Neurodegenerative Diseases - immunology
Neurological diseases
Pathogenesis
pharmacological inhibitors
Pharmacology
Protein Kinase Inhibitors - therapeutic use
Rapamycin
Rheumatoid arthritis
Sepsis
Sepsis - drug therapy
Sepsis - enzymology
Sepsis - immunology
Signal transduction
Signal Transduction - drug effects
Signaling
TOR protein
TOR Serine-Threonine Kinases - antagonists & inhibitors
TOR Serine-Threonine Kinases - immunology
TOR Serine-Threonine Kinases - metabolism
inflamatory diseases
pharmacological inhibitors
mammalian target of rapamycin
inflammation
ISSN:0021-9541, 1097-4652, 1097-4652
Online Access:Get full text
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Summary:Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of mTOR signaling using specific pharmacological inhibitors could offer therapeutic promise in several inflammatory‐associated diseases. In this review, we summarize recent findings on the regulatory effects of mTOR signaling on inflammation and the therapeutic potency of mTOR pharmacological inhibitors in the treatment of inflammatory diseases including cancer, neurodegenerative diseases, atherosclerosis, sepsis, and rheumatoid arthritis for a better understanding and hence a better management of these diseases. In this review, we summarize recent findings on the regulatory effects of mTOR signaling on inflammation and the therapeutic potency of mTOR pharmacological inhibitors in the treatment of inflammatory diseases including cancer, neurodegenerative diseases, atherosclerosis, sepsis, and rheumatoid arthritis for a better understanding and hence a better management of these diseases.
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ISSN:0021-9541
1097-4652
1097-4652
DOI:10.1002/jcp.26276