Overcoming trastuzumab resistance in HER2‐positive breast cancer using combination therapy

Human epidermal growth factor receptor 2 (HER2)‐positive breast cancer (BC) comprises around 20–30% of all BC subtypes and is correlated with poor prognosis. For many years, trastuzumab, a monoclonal antibody, has been used to inhibit the HER2 activity. Though, the main resistance to trastuzumab has...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 235; no. 4; pp. 3142 - 3156
Main Authors:	Derakhshani, Afshin, Rezaei, Zohreh, Safarpour, Hossein, Sabri, Morteza, Mir, Atefeh, Sanati, Mohammad Amin, Vahidian, Fatemeh, Gholamiyan Moghadam, Ali, Aghadoukht, Ali, Hajiasgharzadeh, Khalil, Baradaran, Behzad
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.04.2020
Subjects:	Antineoplastic Agents - pharmacology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Combination therapy drug resistance Drug Resistance, Neoplasm - drug effects Epidermal growth factor ErbB-2 protein Growth factors HER2 positive Humans Immunotherapy Lapatinib - therapeutic use Monoclonal antibodies Receptor, ErbB-2 - drug effects Targeted cancer therapy Trastuzumab Trastuzumab - therapeutic use trastuzumab HER2 positive breast cancer drug resistance
ISSN:	0021-9541, 1097-4652, 1097-4652
Online Access:	Get full text
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