Study of melanocyte density and epidermal thickness in vulvar lichen sclerosus lesions
Objective This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS). Methods Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathologica...
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| Veröffentlicht in: | International journal of dermatology Jg. 60; H. 8; S. 991 - 995 |
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| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
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England
Blackwell Publishing Ltd
01.08.2021
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| ISSN: | 0011-9059, 1365-4632, 1365-4632 |
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| Abstract | Objective
This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).
Methods
Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell‐layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery.
Results
The early VLS (0.170 ± 0.071 µm) and late VLS (0.110 ± 0.035 µm) groups had significantly lower densities of epidermal melanocytes than the control group (0.275 ± 0.036) (F = 36.426, P < 0.001). The cell‐layer thickness did not differ between the early VLS (154.603 ± 121.984 µm) and control (176.974 ± 80.296 µm) groups (P = 0.899) but significantly decreased in the late VLS group (83.455 ± 37.129 µm) compared to the control group (P = 0.003).
Conclusions
Melanocyte density decreased in early and late VLS. The full epidermal and cell‐layer thickness did not significantly change in early VLS, but the cell‐layer thickness decreased in late VLS. |
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| AbstractList | This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).OBJECTIVEThis study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell-layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery.METHODSVulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell-layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery.The early VLS (0.170 ± 0.071 µm) and late VLS (0.110 ± 0.035 µm) groups had significantly lower densities of epidermal melanocytes than the control group (0.275 ± 0.036) (F = 36.426, P < 0.001). The cell-layer thickness did not differ between the early VLS (154.603 ± 121.984 µm) and control (176.974 ± 80.296 µm) groups (P = 0.899) but significantly decreased in the late VLS group (83.455 ± 37.129 µm) compared to the control group (P = 0.003).RESULTSThe early VLS (0.170 ± 0.071 µm) and late VLS (0.110 ± 0.035 µm) groups had significantly lower densities of epidermal melanocytes than the control group (0.275 ± 0.036) (F = 36.426, P < 0.001). The cell-layer thickness did not differ between the early VLS (154.603 ± 121.984 µm) and control (176.974 ± 80.296 µm) groups (P = 0.899) but significantly decreased in the late VLS group (83.455 ± 37.129 µm) compared to the control group (P = 0.003).Melanocyte density decreased in early and late VLS. The full epidermal and cell-layer thickness did not significantly change in early VLS, but the cell-layer thickness decreased in late VLS.CONCLUSIONSMelanocyte density decreased in early and late VLS. The full epidermal and cell-layer thickness did not significantly change in early VLS, but the cell-layer thickness decreased in late VLS. ObjectiveThis study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).MethodsVulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell‐layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery.ResultsThe early VLS (0.170 ± 0.071 µm) and late VLS (0.110 ± 0.035 µm) groups had significantly lower densities of epidermal melanocytes than the control group (0.275 ± 0.036) (F = 36.426, P < 0.001). The cell‐layer thickness did not differ between the early VLS (154.603 ± 121.984 µm) and control (176.974 ± 80.296 µm) groups (P = 0.899) but significantly decreased in the late VLS group (83.455 ± 37.129 µm) compared to the control group (P = 0.003).ConclusionsMelanocyte density decreased in early and late VLS. The full epidermal and cell‐layer thickness did not significantly change in early VLS, but the cell‐layer thickness decreased in late VLS. Objective This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS). Methods Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell‐layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery. Results The early VLS (0.170 ± 0.071 µm) and late VLS (0.110 ± 0.035 µm) groups had significantly lower densities of epidermal melanocytes than the control group (0.275 ± 0.036) (F = 36.426, P < 0.001). The cell‐layer thickness did not differ between the early VLS (154.603 ± 121.984 µm) and control (176.974 ± 80.296 µm) groups (P = 0.899) but significantly decreased in the late VLS group (83.455 ± 37.129 µm) compared to the control group (P = 0.003). Conclusions Melanocyte density decreased in early and late VLS. The full epidermal and cell‐layer thickness did not significantly change in early VLS, but the cell‐layer thickness decreased in late VLS. This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS). Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell-layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. The control group was normal vulvar skin tissues from 15 females after plastic surgery. The early VLS (0.170 ± 0.071 µm) and late VLS (0.110 ± 0.035 µm) groups had significantly lower densities of epidermal melanocytes than the control group (0.275 ± 0.036) (F = 36.426, P < 0.001). The cell-layer thickness did not differ between the early VLS (154.603 ± 121.984 µm) and control (176.974 ± 80.296 µm) groups (P = 0.899) but significantly decreased in the late VLS group (83.455 ± 37.129 µm) compared to the control group (P = 0.003). Melanocyte density decreased in early and late VLS. The full epidermal and cell-layer thickness did not significantly change in early VLS, but the cell-layer thickness decreased in late VLS. |
| Author | Chang, Jianmin Bao, Yingqiu Gao, Xiaoman Fu, Yu Li, Ziyuan |
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This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).
Methods
Vulvar skin tissues were... This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS). Vulvar skin tissues were collected from 15... ObjectiveThis study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).MethodsVulvar skin tissues were... This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).OBJECTIVEThis study aimed to analyze changes... |
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| SubjectTerms | Density Image analysis Image processing Lesions Melanocytes Plastic surgery Skin Stratum corneum Surgery Thickness |
| Title | Study of melanocyte density and epidermal thickness in vulvar lichen sclerosus lesions |
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