5′‐Adenosine monophosphate‐activated protein kinase: A potential target for disease prevention by curcumin

Curcumin (diferuloylmethane), a yellowish agent extracted from turmeric, is a bioactive compound known for its anti‐inflammatory, antiproliferative, antidiabetic, and anticancer activities. Multiple lines of evidence have indicated that curcumin regulates several regulatory proteins in the cellular...

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Bibliographic Details
Published in:Journal of cellular physiology Vol. 234; no. 3; pp. 2241 - 2251
Main Authors: Soltani, Arash, Salmaninejad, Arash, Jalili‐Nik, Mohammad, Soleimani, Anvar, Javid, Hossein, Hashemy, Seyed Isaac, Sahebkar, Amirhossein
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.03.2019
Subjects:
Adenosine
Adenosine kinase
Adenosine monophosphate
Adenosine triphosphate
AMP
AMP-Activated Protein Kinases - antagonists & inhibitors
AMP-Activated Protein Kinases - genetics
AMP‐activated protein kinase
Anticancer properties
Antidiabetics
Apoptosis
Apoptosis - drug effects
Arteriosclerosis
Atherosclerosis
ATP
Bioactive compounds
Curcumin
Curcumin - therapeutic use
Diabetes mellitus
Diabetes Mellitus - drug therapy
Diabetes Mellitus - genetics
Energy balance
Energy metabolism
Energy Metabolism - drug effects
Homeostasis
Humans
Inflammation
Inflammation - drug therapy
Inflammation - genetics
Kinases
Metabolism
Neoplasms - drug therapy
Neoplasms - genetics
Pathogenesis
Prevention
Protein kinase
Proteins
Regulators
Regulatory proteins
Signal transduction
AMP-activated protein kinase
inflammation
curcumin
ISSN:0021-9541, 1097-4652, 1097-4652
Online Access:Get full text
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Summary:Curcumin (diferuloylmethane), a yellowish agent extracted from turmeric, is a bioactive compound known for its anti‐inflammatory, antiproliferative, antidiabetic, and anticancer activities. Multiple lines of evidence have indicated that curcumin regulates several regulatory proteins in the cellular signal transduction pathway. AMP‐activated protein kinase (AMPK) is one of the central regulators of cellular metabolism and energy homeostasis, which is activated in response to increasing cellular adenosine monophosphate/adenosine triphosphate ratio. AMPK plays a critical role in regulating growth and reprogramming metabolism and is linked to several cellular processes including apoptosis and inflammation. Recently, it has been demonstrated that AMPK is a new molecular target affected by curcumin and its derivatives. In this review, we discuss recent findings on the targeting of AMPK signaling by curcumin and the resulting impact on the pathogenesis of proinflammatory diseases. We also highlight the therapeutic value of targeting AMPK by curcumin in the prevention and treatment of proinflammatory diseases, including cancers, atherosclerosis, and diabetes. In this review, we discuss recent findings on the targeting of AMP‐activated protein kinase (AMPK) signaling by curcumin and the resulting impact on the pathogenesis of proinflammatory diseases. We also highlight the therapeutic value of targeting AMPK by curcumin in the prevention and treatment of proinflammatory diseases including cancers, atherosclerosis, and diabetes.
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ISSN:0021-9541
1097-4652
1097-4652
DOI:10.1002/jcp.27192