Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces

Cysteine (Cys) is an enigmatic amino acid residue. Although one of the least abundant, it often occurs in the functional sites of proteins. Whereas free Cys is a polar amino acid, Cys in proteins is often buried, and its classification on the hydrophobicity scale is ambiguous. We hypothesized that t...

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Veröffentlicht in:	Journal of molecular biology Jg. 404; H. 5; S. 902 - 916
Hauptverfasser:	Marino, Stefano M., Gladyshev, Vadim N.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 17.12.2010
Schlagworte:	amino acid conservation Computational Biology - methods Conserved Sequence cysteine Cysteine - chemistry Cysteine - genetics Cysteine - metabolism exposure Hydrophobic and Hydrophilic Interactions hydrophobic scales Protein Folding Protein Structure, Tertiary Proteins - chemistry Proteins - genetics Proteins - metabolism reactive thiols Sec HH exposure cysteine amino acid conservation hydrophobic scales QM reactive thiols PDB
ISSN:	0022-2836, 1089-8638, 1089-8638
Online-Zugang:	Volltext
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