Vascular wall resident progenitor cells: a source for postnatal vasculogenesis

Here, we report the existence of endothelial precursor (EPC) and stem cells in a distinct zone of the vascular wall that are capable to differentiate into mature endothelial cells, hematopoietic and local immune cells, such as macrophages. This zone has been identified to be localized between smooth...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Development (Cambridge) Ročník 133; číslo 8; s. 1543
Hlavní autoři: Zengin, Elvin, Chalajour, Fariba, Gehling, Ursula M, Ito, Wulf D, Treede, Hendrik, Lauke, Heidrun, Weil, Joachim, Reichenspurner, Hermann, Kilic, Nerbil, Ergün, Süleyman
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 15.04.2006
Témata:
Adult
Animals
Antigens, CD34 - metabolism
Cell Differentiation - physiology
Cell Movement - physiology
Cells, Cultured
Endothelial Cells - cytology
Endothelial Cells - metabolism
Endothelial Cells - physiology
Endothelium, Vascular - cytology
Endothelium, Vascular - growth & development
Endothelium, Vascular - metabolism
Humans
Immunohistochemistry
Macrophages - physiology
Neovascularization, Physiologic - physiology
Rats
Receptors, Vascular Endothelial Growth Factor - physiology
Stem Cells - cytology
Stem Cells - physiology
Thoracic Arteries - cytology
Thoracic Arteries - metabolism
Thoracic Arteries - physiology
ISSN:0950-1991
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Here, we report the existence of endothelial precursor (EPC) and stem cells in a distinct zone of the vascular wall that are capable to differentiate into mature endothelial cells, hematopoietic and local immune cells, such as macrophages. This zone has been identified to be localized between smooth muscle and adventitial layer of human adult vascular wall. It predominantly contains CD34-positive (+) but CD31-negative (-) cells, which also express VEGFR2 and TIE2. Only few cells in this zone of the vascular wall are positive for CD45. In a ring assay using the fragments of human internal thoracic artery (HITA), we show here that the CD34+ cells of the HITA-wall form capillary sprouts ex vivo and are apparently recruited for capillary formation by tumor cells. New vessels formed by these vascular wall resident EPCs express markers for angiogenically activated endothelial cells, such as CEACAM1, and also for mature endothelial cells, such as VE-cadherin or occludin. Vascular wall areas containing EPCs are found in large and middle sized arteries and veins of all organs studied here. These data suggest the existence of a ;vasculogenic zone' in the wall of adult human blood vessels, which may serve as a source for progenitor cells for postnatal vasculogenesis, contributing to tumor vascularization and local immune response.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0950-1991
DOI:10.1242/dev.02315