Soluble thrombomodulin protects ischemic kidneys

Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of i...

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Veröffentlicht in:	Journal of the American Society of Nephrology Jg. 20; H. 3; S. 524
Hauptverfasser:	Sharfuddin, Asif A, Sandoval, Ruben M, Berg, David T, McDougal, Grant E, Campos, Silvia B, Phillips, Carrie L, Jones, Bryan E, Gupta, Akanksha, Grinnell, Brian W, Molitoris, Bruce A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2009
Schlagworte:	Animals Base Sequence Capillary Permeability - drug effects Cell Adhesion - drug effects DNA Primers - genetics Fibrinolytic Agents - administration & dosage Genetic Variation Ischemia - prevention & control Kidney - blood supply Kidney - drug effects Kidney - injuries Kidney Tubular Necrosis, Acute - pathology Kidney Tubular Necrosis, Acute - physiopathology Kidney Tubular Necrosis, Acute - prevention & control Leukocytes - drug effects Leukocytes - physiology Male Protein C - metabolism Rats Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recombinant Proteins - genetics Renal Circulation - drug effects Solubility Thrombomodulin - administration & dosage Thrombomodulin - genetics Thrombomodulin - physiology
ISSN:	1533-3450, 1533-3450
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