Evidence of a common cell origin in a case of pancreatic mixed intraductal papillary mucinous neoplasm–neuroendocrine tumor

Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible combinations of mixed neuroendocrine-exocrine neoplasms. Among these, the adenoma plus neuroendocrine tumor (NET) combination is among the rarest and n...

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Veröffentlicht in:Virchows Archiv : an international journal of pathology Jg. 478; H. 6; S. 1215 - 1219
Hauptverfasser: Schiavo Lena, Marco, Cangi, Maria Giulia, Pecciarini, Lorenza, Francaviglia, Ilaria, Grassini, Greta, Maire, Renaud, Partelli, Stefano, Falconi, Massimo, Perren, Aurel, Doglioni, Claudio
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2021
Springer Nature B.V
Schlagworte:
Adenoma
Brief Report
CCND1 gene
Medicine
Medicine & Public Health
Mutation
Neoplasms
Neuroendocrine tumors
Pancreas
Pancreatic cancer
Pathology
Tumors
Intraductal papillary mucinous neoplasm
Mixed neuroendocrine non-neuroendocrine neoplasms
KRAS and GNAS mutation
CDKN2A mutation
Cyclin D1 amplification
Pancreatic neuroendocrine tumor
ISSN:0945-6317, 1432-2307, 1432-2307
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Abstract Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible combinations of mixed neuroendocrine-exocrine neoplasms. Among these, the adenoma plus neuroendocrine tumor (NET) combination is among the rarest and not formally recognized by the 2019 WHO Classification. In this setting, the debate between either collision tumors or true mixed neoplasms is still unsolved. In this report, a pancreatic intraductal papillary mucinous neoplasm (IPMN) plus a NET is described, and the molecular investigations showed the presence in both populations of the same KRAS, GNAS, and CDKN2A mutations and the amplification of the CCND1 gene. These data prove clonality and support a common origin of both components, therefore confirming the true mixed nature. For this reason, mixed neuroendocrine-exocrine neoplasms, in which the exocrine component is represented by a glandular precursor lesion (adenoma/IPMN) only, should be included into the MiNEN family.
AbstractList Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible combinations of mixed neuroendocrine-exocrine neoplasms. Among these, the adenoma plus neuroendocrine tumor (NET) combination is among the rarest and not formally recognized by the 2019 WHO Classification. In this setting, the debate between either collision tumors or true mixed neoplasms is still unsolved. In this report, a pancreatic intraductal papillary mucinous neoplasm (IPMN) plus a NET is described, and the molecular investigations showed the presence in both populations of the same KRAS, GNAS, and CDKN2A mutations and the amplification of the CCND1 gene. These data prove clonality and support a common origin of both components, therefore confirming the true mixed nature. For this reason, mixed neuroendocrine-exocrine neoplasms, in which the exocrine component is represented by a glandular precursor lesion (adenoma/IPMN) only, should be included into the MiNEN family.
Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible combinations of mixed neuroendocrine-exocrine neoplasms. Among these, the adenoma plus neuroendocrine tumor (NET) combination is among the rarest and not formally recognized by the 2019 WHO Classification. In this setting, the debate between either collision tumors or true mixed neoplasms is still unsolved. In this report, a pancreatic intraductal papillary mucinous neoplasm (IPMN) plus a NET is described, and the molecular investigations showed the presence in both populations of the same KRAS, GNAS, and CDKN2A mutations and the amplification of the CCND1 gene. These data prove clonality and support a common origin of both components, therefore confirming the true mixed nature. For this reason, mixed neuroendocrine-exocrine neoplasms, in which the exocrine component is represented by a glandular precursor lesion (adenoma/IPMN) only, should be included into the MiNEN family.Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible combinations of mixed neuroendocrine-exocrine neoplasms. Among these, the adenoma plus neuroendocrine tumor (NET) combination is among the rarest and not formally recognized by the 2019 WHO Classification. In this setting, the debate between either collision tumors or true mixed neoplasms is still unsolved. In this report, a pancreatic intraductal papillary mucinous neoplasm (IPMN) plus a NET is described, and the molecular investigations showed the presence in both populations of the same KRAS, GNAS, and CDKN2A mutations and the amplification of the CCND1 gene. These data prove clonality and support a common origin of both components, therefore confirming the true mixed nature. For this reason, mixed neuroendocrine-exocrine neoplasms, in which the exocrine component is represented by a glandular precursor lesion (adenoma/IPMN) only, should be included into the MiNEN family.
Author Francaviglia, Ilaria
Schiavo Lena, Marco
Maire, Renaud
Pecciarini, Lorenza
Cangi, Maria Giulia
Partelli, Stefano
Doglioni, Claudio
Falconi, Massimo
Perren, Aurel
Grassini, Greta
Author_xml – sequence: 1
  givenname: Marco
  orcidid: 0000-0003-3653-4111
  surname: Schiavo Lena
  fullname: Schiavo Lena, Marco
  email: schiavolena.marco@hsr.it
  organization: Pathology Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 2
  givenname: Maria Giulia
  surname: Cangi
  fullname: Cangi, Maria Giulia
  organization: Pathology Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 3
  givenname: Lorenza
  surname: Pecciarini
  fullname: Pecciarini, Lorenza
  organization: Pathology Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 4
  givenname: Ilaria
  surname: Francaviglia
  fullname: Francaviglia, Ilaria
  organization: Pathology Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 5
  givenname: Greta
  surname: Grassini
  fullname: Grassini, Greta
  organization: Pathology Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 6
  givenname: Renaud
  surname: Maire
  fullname: Maire, Renaud
  organization: Institute of Pathology, University of Bern
– sequence: 7
  givenname: Stefano
  surname: Partelli
  fullname: Partelli, Stefano
  organization: Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 8
  givenname: Massimo
  surname: Falconi
  fullname: Falconi, Massimo
  organization: Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
– sequence: 9
  givenname: Aurel
  surname: Perren
  fullname: Perren, Aurel
  organization: Institute of Pathology, University of Bern
– sequence: 10
  givenname: Claudio
  surname: Doglioni
  fullname: Doglioni, Claudio
  organization: Pathology Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute
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Keywords Intraductal papillary mucinous neoplasm
Mixed neuroendocrine non-neuroendocrine neoplasms
KRAS and GNAS mutation
CDKN2A mutation
Cyclin D1 amplification
Pancreatic neuroendocrine tumor
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SubjectTerms Adenoma
Brief Report
CCND1 gene
Medicine
Medicine & Public Health
Mutation
Neoplasms
Neuroendocrine tumors
Pancreas
Pancreatic cancer
Pathology
Tumors
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Title Evidence of a common cell origin in a case of pancreatic mixed intraductal papillary mucinous neoplasm–neuroendocrine tumor
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