Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreat...

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Veröffentlicht in:Biomarkers Jg. 17; H. 7; S. 618 - 624
Hauptverfasser: Bourouba, Mehdi, Boukercha, Aziza, Zergoun, Ahmed-Amine, Zebboudj, Abderezak, Elhadjan, Mohamed, Djenaoui, Djamel, Asselah, Fatima, Touil-Boukoffa, Chafia
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Informa Healthcare 01.11.2012
Taylor & Francis
Schlagworte:
Adolescent
Adult
Algeria
biomarker
carcinogenesis
Carcinoma - blood
Carcinoma - pathology
Carcinoma - therapy
Case-Control Studies
Humans
inflammation
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - blood
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - therapy
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - prevention & control
nitric oxide
Nitric Oxide - blood
Tumor Burden
UCNT
Young Adult
Algeria
ISSN:1354-750X, 1366-5804, 1366-5804
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Abstract Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.
AbstractList Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.
Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.
Author Bourouba, Mehdi
Elhadjan, Mohamed
Asselah, Fatima
Djenaoui, Djamel
Boukercha, Aziza
Zebboudj, Abderezak
Touil-Boukoffa, Chafia
Zergoun, Ahmed-Amine
Author_xml – sequence: 1
  givenname: Mehdi
  surname: Bourouba
  fullname: Bourouba, Mehdi
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: USTHB, Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric oxide synthases, Immunity and pathogeny, Faculty of biological sciences
– sequence: 2
  givenname: Aziza
  surname: Boukercha
  fullname: Boukercha, Aziza
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: USTHB, Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric oxide synthases, Immunity and pathogeny, Faculty of biological sciences
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  givenname: Ahmed-Amine
  surname: Zergoun
  fullname: Zergoun, Ahmed-Amine
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: USTHB, Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric oxide synthases, Immunity and pathogeny, Faculty of biological sciences
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  givenname: Abderezak
  surname: Zebboudj
  fullname: Zebboudj, Abderezak
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: USTHB, Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric oxide synthases, Immunity and pathogeny, Faculty of biological sciences
– sequence: 5
  givenname: Mohamed
  surname: Elhadjan
  fullname: Elhadjan, Mohamed
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: Oto-rhyno-laryngology department, Mustapha Pacha Hospital, Faculty of Medicine
– sequence: 6
  givenname: Djamel
  surname: Djenaoui
  fullname: Djenaoui, Djamel
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: Oto-rhyno-laryngology department, Mustapha Pacha Hospital, Faculty of Medicine
– sequence: 7
  givenname: Fatima
  surname: Asselah
  fullname: Asselah, Fatima
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: Anatomo-pathology department, Mustapha Pacha Hospital, Faculty of Medicine
– sequence: 8
  givenname: Chafia
  surname: Touil-Boukoffa
  fullname: Touil-Boukoffa, Chafia
  email: mbourouba@usthb.dz, mbourouba@usthb.dz
  organization: USTHB, Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric oxide synthases, Immunity and pathogeny, Faculty of biological sciences
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Snippet Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of...
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SubjectTerms Adolescent
Adult
Algeria
biomarker
carcinogenesis
Carcinoma - blood
Carcinoma - pathology
Carcinoma - therapy
Case-Control Studies
Humans
inflammation
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - blood
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - therapy
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - prevention & control
nitric oxide
Nitric Oxide - blood
Tumor Burden
UCNT
Young Adult
Title Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma
URI https://www.tandfonline.com/doi/abs/10.3109/1354750X.2012.706643
https://www.ncbi.nlm.nih.gov/pubmed/22817561
https://www.proquest.com/docview/1114696927
Volume 17
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