Skeletal muscle proteome analysis underpins multifaceted mitochondrial dysfunction in Friedreich’s ataxia

Friedreich’s ataxia (FRDA) is a severe multisystemic disorder caused by a deficiency of the mitochondrial protein frataxin. While some aspects of FRDA pathology are developmental, the causes underlying the steady progression are unclear. The inaccessibility of key affected tissues to sampling is a m...

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Vydané v:	Frontiers in neuroscience Ročník 17; s. 1289027
Hlavní autori:	Indelicato, Elisabetta, Faserl, Klaus, Amprosi, Matthias, Nachbauer, Wolfgang, Schneider, Rainer, Wanschitz, Julia, Sarg, Bettina, Boesch, Sylvia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Lausanne Frontiers Research Foundation 31.10.2023 Frontiers Media S.A
Predmet:	Acids Ataxia Biomarkers Biopsy Chromatography Frataxin Friedreich’s ataxia Glycolysis Mass spectrometry Mitochondria Muscle contraction Musculoskeletal system Oxidative phosphorylation Pathophysiology Peptides Phenotypes Phosphorylation Principal components analysis Protein deficiency Proteins Proteomes Proteomics Scientific imaging Skeletal muscle Solvents
ISSN:	1662-453X, 1662-4548, 1662-453X
On-line prístup:	Získať plný text
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