Strontium-doped bioactive glass/PDA functionalized polyetheretherketone with immunomodulatory property for enhancing photothermal clearance of Staphylococcus aureus

[Display omitted] •SPK-SP was fabricated on PEEK implants surface by a simple strategy at ambient temperature.•SPK-SP showed multifunction of immune-modulatory and antibacterial and superior photothermal effect.•SPK-SP exhibited excellent antibacterial and anti-biofilm efficiency in vitro and in viv...

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Vydané v:Materials & design Ročník 225; s. 111552
Hlavní autori: Su, Xinjin, Lyu, Zhuocheng, Wu, Yuezhou, Gu, Yue-Huan, Huo, Shicheng, Zhou, Chun
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Elsevier Ltd 01.01.2023
Elsevier
Predmet:
Bioactive glass
Biofilm
Implant infections
Photothermal effect
Polydopamine
Biofilm
Polydopamine
Bioactive glass
Photothermal effect
Implant infections
ISSN:0264-1275, 1873-4197
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Shrnutí:[Display omitted] •SPK-SP was fabricated on PEEK implants surface by a simple strategy at ambient temperature.•SPK-SP showed multifunction of immune-modulatory and antibacterial and superior photothermal effect.•SPK-SP exhibited excellent antibacterial and anti-biofilm efficiency in vitro and in vivo.•SPK-SP favored macrophage polarization to M2 anti-inflammatory microenvironment to promote tissue repair following infection. The infection of implants following orthopedic surgery is a “catastrophic” surgical complication, particularly when biofilms form, protecting bacteria from antibiotics as well as the patient’s immune system. To address the current difficulties in treating biofilm infections, we fabricate a functional strontium doped bioactive glass nanoparticles (Sr-BGNs)-instructed orthopedic implant composed of PEEK, Sr-BGNs and polydopamine (PDA). In addition to destroying the permeability and integrity of MRSA biofilm, PDA also endowed PEEK substrate with effective antibacterial ability when exposing to near-infrared (NIR) irradiation. The NIR mediated photothermal disruption of biofilms contributed to the advanced antibacterial therapy, which has been validated by the efficient eradication of methicillin-resistant Staphylococcus aureus strains (MRSA) biofilm in vitro and in vivo. Notably, the engineered implants exhibit satisfactory cytocompatibility. In addition, Sr ions released from Sr-BGNs inhibited the expression of inflammatory genes, thereby providing a superior environment for tissue repair after infection clearance. The synergistic effect of photothermal effect and immunomodulatory property might have promising applications for preventing perioperative infection and tissue repair after infection.
ISSN:0264-1275
1873-4197
DOI:10.1016/j.matdes.2022.111552