Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor

The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL and is an important therapeutic target for treating cardiovascular disease. Abundance of the LDLR is subject to both transcriptional and nontranscriptional control. Here, we highlight a new post-tra...

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Veröffentlicht in:	Current opinion in lipidology Jg. 23; H. 3; S. 213
Hauptverfasser:	Sorrentino, Vincenzo, Zelcer, Noam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.06.2012
Schlagworte:	Animals Humans Lipoproteins, LDL - metabolism Low Density Lipoprotein Receptor-Related Protein-1 - metabolism Proteolysis Receptors, LDL - genetics Receptors, LDL - metabolism Transcription, Genetic Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
ISSN:	1473-6535, 1473-6535
Online-Zugang:	Weitere Angaben
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