Inflammation and Stroke Risk: A New Target for Prevention

New therapeutic approaches are required for secondary prevention of residual vascular risk after stroke. Diverse sources of evidence support a causal role for inflammation in the pathogenesis of stroke. Randomized controlled trials of anti-inflammatory agents have reported benefit for secondary prev...

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Bibliographic Details
Published in:Stroke (1970) Vol. 52; no. 8; p. 2697
Main Authors: Kelly, Peter J, Lemmens, Robin, Tsivgoulis, Georgios
Format: Journal Article
Language:English
Published: United States 01.08.2021
Subjects:
Animals
Anti-Inflammatory Agents - administration & dosage
Colchicine - administration & dosage
Drug Delivery Systems - methods
Drug Delivery Systems - trends
Gout Suppressants - administration & dosage
Humans
Inflammation - diagnosis
Inflammation - epidemiology
Inflammation - prevention & control
Mendelian Randomization Analysis - methods
Observational Studies as Topic - methods
Risk Factors
Secondary Prevention - methods
Secondary Prevention - trends
Stroke - diagnosis
Stroke - epidemiology
Stroke - prevention & control
macrophage
atrial fibrillation
subtilisin
inflammation
pyrin
ISSN:1524-4628, 1524-4628
Online Access:Get more information
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Summary:New therapeutic approaches are required for secondary prevention of residual vascular risk after stroke. Diverse sources of evidence support a causal role for inflammation in the pathogenesis of stroke. Randomized controlled trials of anti-inflammatory agents have reported benefit for secondary prevention in patients with coronary disease. We review the data from observational studies supporting a role for inflammation in pathogenesis of stroke, overview randomized controlled trials of anti-inflammatory therapy in cardiac disease and discuss the potential implications for stroke prevention therapy.
Bibliography:ObjectType-Article-1
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ISSN:1524-4628
1524-4628
DOI:10.1161/STROKEAHA.121.034388