A Systematic Review of the Effect of Rotavirus Vaccination on Diarrhea Outcomes Among Children Younger Than 5 Years

Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 globally. Rotavirus vaccination has been shown to prevent severe rotavirus infections with varying efficacy and effectiveness by region. We sought to generate updated region-specific estimates of rotavirus vaccine...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	The Pediatric infectious disease journal Ročník 35; číslo 9; s. 992
Hlavní autoři:	Lamberti, Laura M, Ashraf, Sania, Walker, Christa L Fischer, Black, Robert E
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.09.2016
Témata:	Africa South of the Sahara - epidemiology Asia - epidemiology Child, Preschool Developing Countries Diarrhea - epidemiology Diarrhea - mortality Diarrhea - prevention & control Diarrhea - virology Humans Infant Infant, Newborn Latin America - epidemiology Rotavirus Rotavirus Infections - epidemiology Rotavirus Infections - mortality Rotavirus Infections - prevention & control Rotavirus Infections - virology Rotavirus Vaccines Vaccination - statistics & numerical data
ISSN:	1532-0987, 1532-0987
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 globally. Rotavirus vaccination has been shown to prevent severe rotavirus infections with varying efficacy and effectiveness by region. We sought to generate updated region-specific estimates of rotavirus vaccine efficacy and effectiveness. We systematically reviewed published vaccine efficacy and effectiveness studies to assess the region-specific effect of rotavirus vaccination on select diarrheal morbidity and mortality outcomes in children under 5 years of age. We employed meta-analytic methods to generate pooled effect sizes by Millennium Development Goal region. Rotavirus vaccination was both efficacious and effective in preventing rotavirus diarrhea, severe rotavirus diarrhea and rotavirus hospitalizations among children under 5 across all regions represented by the 48 included studies. Efficacy against severe rotavirus diarrhea ranged from 90.6% [95% confidence interval (CI): 82.3-95.0] in the developed region to 88.4% (95% CI: 67.1-95.9) in Eastern/Southeastern Asia, 79.6% (95% CI: 71.3-85.5) in Latin America and the Caribbean, 50.0% (95% CI: 34.4-61.9) in Southern Asia and 46.1% (95% CI: 29.1-59.1) in sub-Saharan Africa. Region-specific effectiveness followed a similar pattern. There was also evidence of vaccine efficacy against severe diarrhea and diarrheal hospitalizations. Our findings confirm the protective efficacy and effectiveness of rotavirus vaccination against rotavirus diarrheal outcomes among children under 5 globally.
AbstractList	Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 globally. Rotavirus vaccination has been shown to prevent severe rotavirus infections with varying efficacy and effectiveness by region.BACKGROUNDRotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 globally. Rotavirus vaccination has been shown to prevent severe rotavirus infections with varying efficacy and effectiveness by region.We sought to generate updated region-specific estimates of rotavirus vaccine efficacy and effectiveness. We systematically reviewed published vaccine efficacy and effectiveness studies to assess the region-specific effect of rotavirus vaccination on select diarrheal morbidity and mortality outcomes in children under 5 years of age. We employed meta-analytic methods to generate pooled effect sizes by Millennium Development Goal region.METHODSWe sought to generate updated region-specific estimates of rotavirus vaccine efficacy and effectiveness. We systematically reviewed published vaccine efficacy and effectiveness studies to assess the region-specific effect of rotavirus vaccination on select diarrheal morbidity and mortality outcomes in children under 5 years of age. We employed meta-analytic methods to generate pooled effect sizes by Millennium Development Goal region.Rotavirus vaccination was both efficacious and effective in preventing rotavirus diarrhea, severe rotavirus diarrhea and rotavirus hospitalizations among children under 5 across all regions represented by the 48 included studies. Efficacy against severe rotavirus diarrhea ranged from 90.6% [95% confidence interval (CI): 82.3-95.0] in the developed region to 88.4% (95% CI: 67.1-95.9) in Eastern/Southeastern Asia, 79.6% (95% CI: 71.3-85.5) in Latin America and the Caribbean, 50.0% (95% CI: 34.4-61.9) in Southern Asia and 46.1% (95% CI: 29.1-59.1) in sub-Saharan Africa. Region-specific effectiveness followed a similar pattern. There was also evidence of vaccine efficacy against severe diarrhea and diarrheal hospitalizations.RESULTSRotavirus vaccination was both efficacious and effective in preventing rotavirus diarrhea, severe rotavirus diarrhea and rotavirus hospitalizations among children under 5 across all regions represented by the 48 included studies. Efficacy against severe rotavirus diarrhea ranged from 90.6% [95% confidence interval (CI): 82.3-95.0] in the developed region to 88.4% (95% CI: 67.1-95.9) in Eastern/Southeastern Asia, 79.6% (95% CI: 71.3-85.5) in Latin America and the Caribbean, 50.0% (95% CI: 34.4-61.9) in Southern Asia and 46.1% (95% CI: 29.1-59.1) in sub-Saharan Africa. Region-specific effectiveness followed a similar pattern. There was also evidence of vaccine efficacy against severe diarrhea and diarrheal hospitalizations.Our findings confirm the protective efficacy and effectiveness of rotavirus vaccination against rotavirus diarrheal outcomes among children under 5 globally.CONCLUSIONOur findings confirm the protective efficacy and effectiveness of rotavirus vaccination against rotavirus diarrheal outcomes among children under 5 globally. Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 globally. Rotavirus vaccination has been shown to prevent severe rotavirus infections with varying efficacy and effectiveness by region. We sought to generate updated region-specific estimates of rotavirus vaccine efficacy and effectiveness. We systematically reviewed published vaccine efficacy and effectiveness studies to assess the region-specific effect of rotavirus vaccination on select diarrheal morbidity and mortality outcomes in children under 5 years of age. We employed meta-analytic methods to generate pooled effect sizes by Millennium Development Goal region. Rotavirus vaccination was both efficacious and effective in preventing rotavirus diarrhea, severe rotavirus diarrhea and rotavirus hospitalizations among children under 5 across all regions represented by the 48 included studies. Efficacy against severe rotavirus diarrhea ranged from 90.6% [95% confidence interval (CI): 82.3-95.0] in the developed region to 88.4% (95% CI: 67.1-95.9) in Eastern/Southeastern Asia, 79.6% (95% CI: 71.3-85.5) in Latin America and the Caribbean, 50.0% (95% CI: 34.4-61.9) in Southern Asia and 46.1% (95% CI: 29.1-59.1) in sub-Saharan Africa. Region-specific effectiveness followed a similar pattern. There was also evidence of vaccine efficacy against severe diarrhea and diarrheal hospitalizations. Our findings confirm the protective efficacy and effectiveness of rotavirus vaccination against rotavirus diarrheal outcomes among children under 5 globally.
Author	Black, Robert E Ashraf, Sania Walker, Christa L Fischer Lamberti, Laura M
Author_xml	– sequence: 1 givenname: Laura M surname: Lamberti fullname: Lamberti, Laura M organization: From the Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland – sequence: 2 givenname: Sania surname: Ashraf fullname: Ashraf, Sania – sequence: 3 givenname: Christa L Fischer surname: Walker fullname: Walker, Christa L Fischer – sequence: 4 givenname: Robert E surname: Black fullname: Black, Robert E
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27254030$$D View this record in MEDLINE/PubMed
BookMark	eNpNkFtLAzEQhYNU7EX_gUgefdmay14fS221UCzUKvRpyWYn3Ug3qclupf_eFRU6DJxz4GMOzBD1jDWA0C0lY0qy5GHxMh-Ts6GMsws0oBFnAcnSpHfm-2jo_UcH8ZCSK9RnCYtCwskA-Ql-PfkGatFoiddw1PCFrcJNBXimFMjmJ61tI47atR6_Cym16WBrcLePWjhXgcCrtpG2Bo8ntTU7PK30vnRg8Na2ZgcObyphcIS3IJy_RpdK7D3c_OkIvc1nm-lzsFw9LaaTZSBDmsZBSuMoKyDLhGI8oZBwKqkiISsilYoSMhWFPBZZBBRkAQRoKMKExXFWchUlko3Q_e_dg7OfLfgmr7WXsN8LA7b1OU0pS9Owq-nQuz-0LWoo84PTtXCn_P9R7BtOOGyd
CitedBy_id	crossref_primary_10_1093_cid_ciab520 crossref_primary_10_1371_journal_pone_0297219 crossref_primary_10_52976_vansaglik_751249 crossref_primary_10_1016_j_pedneo_2022_06_012 crossref_primary_10_1093_cid_ciac699 crossref_primary_10_1172_JCI171966 crossref_primary_10_1016_j_vaccine_2020_11_034 crossref_primary_10_1016_j_vaccine_2021_11_033 crossref_primary_10_1016_j_vaccine_2018_03_069 crossref_primary_10_1186_s12879_018_3615_6 crossref_primary_10_1093_cid_cix1022 crossref_primary_10_1016_j_vaccine_2022_05_042 crossref_primary_10_1093_infdis_jix187 crossref_primary_10_1371_journal_pone_0284934 crossref_primary_10_1056_NEJMoa1716766 crossref_primary_10_1097_INF_0000000000001907 crossref_primary_10_1186_s12916_018_1074_y crossref_primary_10_3389_fimmu_2018_00532 crossref_primary_10_1093_infdis_jiae055 crossref_primary_10_1016_j_vaccine_2019_07_030 crossref_primary_10_1016_j_cej_2024_156888 crossref_primary_10_1016_j_chom_2022_04_006 crossref_primary_10_1038_s41541_024_00872_6 crossref_primary_10_1080_14760584_2020_1775079 crossref_primary_10_1371_journal_pone_0251905 crossref_primary_10_1007_s12098_020_03614_3 crossref_primary_10_1007_s40475_018_0134_x crossref_primary_10_1097_MD_0000000000006574 crossref_primary_10_1002_rmv_2259 crossref_primary_10_1016_j_jbiotec_2018_06_306 crossref_primary_10_1080_14760584_2020_1775081 crossref_primary_10_1093_cid_ciad015 crossref_primary_10_1016_j_vaccine_2017_03_076 crossref_primary_10_1016_j_vaccine_2017_10_062 crossref_primary_10_1038_s41586_020_2238_4 crossref_primary_10_12659_AJCR_901978 crossref_primary_10_2188_jea_JE20200066 crossref_primary_10_1007_s00705_024_05975_y crossref_primary_10_3390_ijms18020431 crossref_primary_10_1001_jamapediatrics_2021_0347 crossref_primary_10_3389_fimmu_2017_00334 crossref_primary_10_1016_S1473_3099_19_30126_4 crossref_primary_10_1093_cid_ciac910 crossref_primary_10_1371_journal_pone_0222531 crossref_primary_10_1186_s40249_019_0609_6 crossref_primary_10_7189_jogh_09_020801 crossref_primary_10_1016_j_meegid_2017_11_007 crossref_primary_10_1016_j_vaccine_2020_10_052 crossref_primary_10_3390_ijerph22050706 crossref_primary_10_1038_s41598_018_32595_9 crossref_primary_10_1016_j_ijid_2018_06_006 crossref_primary_10_1038_s41541_021_00316_5 crossref_primary_10_3389_fcimb_2021_625210 crossref_primary_10_1016_j_eclinm_2025_103122 crossref_primary_10_3390_vaccines9050437 crossref_primary_10_1136_bmjopen_2018_024840 crossref_primary_10_7554_eLife_67635 crossref_primary_10_1080_14760584_2021_1951247 crossref_primary_10_3748_wjg_v23_i45_7952 crossref_primary_10_1016_j_vaccine_2018_02_009 crossref_primary_10_1002_jmv_70468 crossref_primary_10_1016_j_vaccine_2018_02_008 crossref_primary_10_3390_vaccines7040177 crossref_primary_10_1016_j_virusres_2017_09_023 crossref_primary_10_1097_QCO_0000000000000475 crossref_primary_10_1016_j_vaccine_2019_01_061 crossref_primary_10_1038_s41541_020_0193_6 crossref_primary_10_1016_j_vaccine_2020_03_022 crossref_primary_10_1093_aje_kwae467 crossref_primary_10_1016_j_vaccine_2024_05_012 crossref_primary_10_1093_ofid_ofy292 crossref_primary_10_1001_jamapediatrics_2018_1960 crossref_primary_10_1038_s41541_023_00632_y crossref_primary_10_3390_vaccines11081299 crossref_primary_10_12688_wellcomeopenres_16090_1 crossref_primary_10_1093_cid_ciz060 crossref_primary_10_1016_S0140_6736_16_31593_8
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1097/INF.0000000000001232
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1532-0987
ExternalDocumentID	27254030
Genre	Meta-Analysis Systematic Review Journal Article
GroupedDBID	--- .-D .3C .GJ .XZ .Z2 01R 0R~ 123 1J1 40H 4Q1 4Q2 4Q3 53G 5RE 5VS 71W 77Y 7O~ 8L- AAAAV AAAXR AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AAQQT AARTV AASCR AASOK AAUEB AAXQO ABASU ABBUW ABDIG ABJNI ABPPZ ABPXF ABVCZ ABXVJ ABXYN ABZAD ABZZY ACCJW ACDDN ACDOF ACEWG ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ACZKN ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEBDS AEETU AENEX AFBFQ AFDTB AFEXH AFFNX AFMBP AFNMH AFSOK AFUWQ AGINI AHOMT AHQNM AHQVU AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BOYCO BQLVK BS7 BYPQX C45 CGR CS3 CUY CVF DIWNM DU5 DUNZO E.X EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL H0~ HLJTE HZ~ IKREB IKYAY IN~ IPNFZ JF9 JG8 JK3 JK8 K8S KD2 KMI L-C N9A NPM N~7 N~B N~M O9- OAG OAH OCUKA ODA ODMTH OHYEH OK1 OL1 OLG OLH OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OVOZU OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ S4R S4S SJN T8P TEORI TSPGW V2I VVN W3M WOQ WOW X3V X3W XXN XYM YFH YOC ZGI ZXP ZZMQN 7X8 ADKSD ADSXY
ID	FETCH-LOGICAL-c4186-81659be99af2371e731c1f042b5f8ade9f5436a95e1ecbe0e14a472669d3f57c2
IEDL.DBID	7X8
ISICitedReferencesCount	88
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=00006454-201609000-00016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1532-0987
IngestDate	Mon Sep 08 03:04:27 EDT 2025 Sat Jun 28 01:34:49 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	9
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4186-81659be99af2371e731c1f042b5f8ade9f5436a95e1ecbe0e14a472669d3f57c2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Undefined-4
PMID	27254030
PQID	1812884165
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1812884165 pubmed_primary_27254030
PublicationCentury	2000
PublicationDate	2016-09-00 20160901
PublicationDateYYYYMMDD	2016-09-01
PublicationDate_xml	– month: 09 year: 2016 text: 2016-09-00
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	The Pediatric infectious disease journal
PublicationTitleAlternate	Pediatr Infect Dis J
PublicationYear	2016
SSID	ssj0003410
Score	2.4804645
SecondaryResourceType	review_article
Snippet	Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 globally. Rotavirus vaccination has been shown to prevent severe...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	992
SubjectTerms	Africa South of the Sahara - epidemiology Asia - epidemiology Child, Preschool Developing Countries Diarrhea - epidemiology Diarrhea - mortality Diarrhea - prevention & control Diarrhea - virology Humans Infant Infant, Newborn Latin America - epidemiology Rotavirus Rotavirus Infections - epidemiology Rotavirus Infections - mortality Rotavirus Infections - prevention & control Rotavirus Infections - virology Rotavirus Vaccines Vaccination - statistics & numerical data
Title	A Systematic Review of the Effect of Rotavirus Vaccination on Diarrhea Outcomes Among Children Younger Than 5 Years
URI	https://www.ncbi.nlm.nih.gov/pubmed/27254030 https://www.proquest.com/docview/1812884165
Volume	35
WOSCitedRecordID	wos00006454-201609000-00016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDI6AIcSF92O8FCSu1dr0keaEpsEEh5UJBhqnyW0dsUs72m2_H6ft4ISERFVVyiFSmtifnTj-zNiNYdmXRtPItFcpObYFISgLYhPWAvRT9KpiEzKKwvFYDZsDt7K5VrnCxAqo0zwxZ-QdY4lCEyPzb2eflqkaZaKrTQmNddZyyZUxUi3HP2zhhNB2zZcqLJs216vUOSU7j1G_pi5sHuNZ_O5kVsamv_vfYe6xncbN5N1aLvbZGmYHbGvQBNIPWdnlL98czrwOEPBcc3IHeU1obFrP-RyW02JR8jdIqGO1ipzeuykUBcE4f1rMaVxY8q4pWsR7TWo4r0AECz76gIz7_J30qTxir_37Ue_BauovWInnhIEV0l-oGJUCLVzpoHSdxNGk5bGvQ0hRad9zA1A-OpjEaKPjgSfJ4qvU1b5MxDHbyPIMTxkXtueA0nEgREqQkcagABwEN7FRq1C02fVqOick3yZoARnmi3LyM6FtdlKvyWRWE3FMhKTtLaHU2R96n7Nt8nWC-nrYBWtp0m68ZJvJcj4ti6tKcOgbDQdfNcnLqA
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Systematic+Review+of+the+Effect+of+Rotavirus+Vaccination+on+Diarrhea+Outcomes+Among+Children+Younger+Than+5+Years&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.au=Lamberti%2C+Laura+M&rft.au=Ashraf%2C+Sania&rft.au=Walker%2C+Christa+L+Fischer&rft.au=Black%2C+Robert+E&rft.date=2016-09-01&rft.eissn=1532-0987&rft.volume=35&rft.issue=9&rft.spage=992&rft_id=info:doi/10.1097%2FINF.0000000000001232&rft_id=info%3Apmid%2F27254030&rft_id=info%3Apmid%2F27254030&rft.externalDocID=27254030
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1532-0987&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1532-0987&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1532-0987&client=summon