Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders

To investigate whether transvascular indocyanine green (ICG) dye leakage is associated with conjunctival malignancy. This is a prospective interventional study. Patients presenting with circumscribed conjunctival melanocytic disorders (CMDs) were included and examined using color photography, anteri...

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Vydáno v:Cornea Ročník 40; číslo 12; s. 1519
Hlavní autoři: Palme, Christoph, Wanner, Astrid, Romano, Vito, Franchi, Alexander, Haas, Gertrud, Kaye, Stephen B, Steger, Bernhard
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.12.2021
Témata:
Adult
Aged
Aged, 80 and over
Coloring Agents - pharmacology
Conjunctiva - blood supply
Conjunctiva - pathology
Conjunctival Neoplasms - blood supply
Conjunctival Neoplasms - diagnosis
Female
Fluorescein Angiography - methods
Follow-Up Studies
Fundus Oculi
Humans
Indocyanine Green - pharmacology
Male
Melanoma - blood supply
Melanoma - diagnosis
Middle Aged
Prospective Studies
Tomography, Optical Coherence - methods
ISSN:1536-4798, 1536-4798
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Shrnutí:To investigate whether transvascular indocyanine green (ICG) dye leakage is associated with conjunctival malignancy. This is a prospective interventional study. Patients presenting with circumscribed conjunctival melanocytic disorders (CMDs) were included and examined using color photography, anterior segment optical coherence tomography to measure lesion size, and fluorescein and ICG angiography to measure vascular pattern and leakage. Time to vascular leakage was measured by 2 independent observers. Lesions were characterized as benign or malignant based on histopathological features. Thirty patients with CMD were included: 22 lesions were benign (conjunctival nevus, n = 20; conjunctival melanocytic intraepithelial neoplasia without atypia, n = 2) and 8 were malignant (in situ conjunctival melanoma n = 2; invasive conjunctival melanoma, n = 6). Malignant lesions had larger mean maximal diameters (11.0 ± 4.5 vs. 4.2 ± 2.5 mm, P = 0.003) and more frequently showed intrinsic tumor vasculature (8 of 8 vs. 10 of 22, P = 0.007). The mean time to ICG leakage was 350.9 ± 165.9 seconds in benign and 59.6 ± 22.1 seconds (P = 0.002) in malignant lesions and was inversely correlated with lesion size and thickness. Time to angiographic ICG dye leakage is significantly shorter in malignant versus benign CMD.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1536-4798
1536-4798
DOI:10.1097/ICO.0000000000002681