The 14‐3‐3/SLP76 protein–protein interaction in T‐cell receptor signalling: a structural and biophysical characterization

The SH2 domain‐containing protein of 76 kDa, SLP76, is an important adaptor protein that coordinates a complex protein network downstream of T‐cell receptors (TCR), ultimately regulating the immune response. Upon phosphorylation on Ser376, SLP76 interacts with 14‐3‐3 adaptor proteins, which leads to...

Full description

Saved in:

Bibliographic Details
Published in:	FEBS letters Vol. 595; no. 3; pp. 404 - 414
Main Authors:	Soini, Lorenzo, Leysen, Seppe, Davis, Jeremy, Westwood, Marta, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	England 01.02.2021
Subjects:	calorimetry crystal structure fluorescence immune response isothermal titration calorimetry phosphorylation protein constructs protein-protein interactions proteolysis surface plasmon resonance synthetic peptides T-lymphocytes TCR signalling and 14‐3‐3 titration X‐ray protein crystallography isothermal titration calorimetry protein constructs surface plasmon resonance TCR signalling and 14-3-3 X-ray protein crystallography
ISSN:	0014-5793, 1873-3468, 1873-3468
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!