Multimodality approach to optical early detection and mapping of oral neoplasia

Early detection of cancer remains the best way to ensure patient survival and quality of life. Squamous cell carcinoma is usually preceded by dysplasia presenting as white, red, or mixed red and white epithelial lesions on the oral mucosa (leukoplakia, erythroplakia). Dysplastic lesions in the form...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Journal of biomedical optics Ročník 16; číslo 7; s. 076007
Hlavní autoři:	Ahn, Yeh-Chan, Chung, Jungrae, Wilder-Smith, Petra, Chen, Zhongping
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2011
Témata:	9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Carcinogens - toxicity Carcinoma, Squamous Cell - diagnosis Cricetinae Humans Image Enhancement Imaging, Three-Dimensional Leukoplakia, Oral - diagnosis Mesocricetus Mouth Neoplasms - chemically induced Mouth Neoplasms - diagnosis Neoplasms, Experimental - chemically induced Neoplasms, Experimental - diagnosis Scanning Laser Polarimetry - methods Tomography, Optical Coherence - methods
ISSN:	1560-2281, 1560-2281
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Early detection of cancer remains the best way to ensure patient survival and quality of life. Squamous cell carcinoma is usually preceded by dysplasia presenting as white, red, or mixed red and white epithelial lesions on the oral mucosa (leukoplakia, erythroplakia). Dysplastic lesions in the form of erythroplakia can carry a risk for malignant conversion of 90%. A noninvasive diagnostic modality would enable monitoring of these lesions at regular intervals and detection of treatment needs at a very early, relatively harmless stage. The specific aim of this work was to test a multimodality approach [three-dimensional optical coherence tomography (OCT) and polarimetry] to noninvasive diagnosis of oral premalignancy and malignancy using the hamster cheek pouch model (nine hamsters). The results were compared to tissue histopathology. During carcinogenesis, epithelial down grow, eventual loss of basement membrane integrity, and subepithelial invasion were clearly visible with OCT. Polarimetry techniques identified a four to five times increased retardance in sites with squamous cell carcinoma, and two to three times greater retardance in dysplastic sites than in normal tissues. These techniques were particularly useful for mapping areas of field cancerization with multiple lesions, as well as lesion margins.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1560-2281 1560-2281
DOI:	10.1117/1.3595850