Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene

We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated le...

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Veröffentlicht in:	Diabetes research and clinical practice Jg. 71; H. 3; S. 233 - 240
Hauptverfasser:	Oh, Tae Keun, Li, Mei Zi, Kim, Seung Taik
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Ireland Elsevier Ireland Ltd 01.03.2006
Schlagworte:	Animals Cell Line Diabetes Mellitus, Experimental - drug therapy Genes, Reporter Genetic Therapy - methods Genetic Vectors Green Fluorescent Proteins - genetics HeLa Cells Humans Injections, Intramuscular Insulin - administration & dosage Insulin - genetics Insulin - therapeutic use Insulin gene therapy Intramuscular injection Lentivirus Lentivirus - genetics Male Mice Proinsulin - genetics Promoter Regions, Genetic Rats Rats, Inbred F344 Insulin gene therapy Lentivirus Intramuscular injection
ISSN:	0168-8227, 1872-8227
Online-Zugang:	Volltext
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