Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene
We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated le...
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| Veröffentlicht in: | Diabetes research and clinical practice Jg. 71; H. 3; S. 233 - 240 |
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| Abstract | We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated lentiviral vector (3.5
μg p24 Gag antigen) carrying the insulin gene into the thigh muscle, treated rats demonstrated an increase in body weight, increased survivability, attenuated the hyperglycemic response as well as prevented the formation of ketoacidosis. For these reasons, the intraparenchymal injection of lentiviral vectors into the skeletal muscle to ectopically produce insulin may be an easy and therapeutic treatment modality for type 1 diabetes mellitus. |
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| AbstractList | We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated lentiviral vector (3.5
μg p24 Gag antigen) carrying the insulin gene into the thigh muscle, treated rats demonstrated an increase in body weight, increased survivability, attenuated the hyperglycemic response as well as prevented the formation of ketoacidosis. For these reasons, the intraparenchymal injection of lentiviral vectors into the skeletal muscle to ectopically produce insulin may be an easy and therapeutic treatment modality for type 1 diabetes mellitus. We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated lentiviral vector (3.5 microg p24 Gag antigen) carrying the insulin gene into the thigh muscle, treated rats demonstrated an increase in body weight, increased survivability, attenuated the hyperglycemic response as well as prevented the formation of ketoacidosis. For these reasons, the intraparenchymal injection of lentiviral vectors into the skeletal muscle to ectopically produce insulin may be an easy and therapeutic treatment modality for type 1 diabetes mellitus.We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated lentiviral vector (3.5 microg p24 Gag antigen) carrying the insulin gene into the thigh muscle, treated rats demonstrated an increase in body weight, increased survivability, attenuated the hyperglycemic response as well as prevented the formation of ketoacidosis. For these reasons, the intraparenchymal injection of lentiviral vectors into the skeletal muscle to ectopically produce insulin may be an easy and therapeutic treatment modality for type 1 diabetes mellitus. We assessed therapeutic potential of intramuscular insulin gene delivery in a diabetic murine model. The human proinsulin gene cDNA engineered with concensus furin cleavage sequences was inserted into an advanced lentiviral vector that contained CMV early promoter. After injection of concentrated lentiviral vector (3.5 microg p24 Gag antigen) carrying the insulin gene into the thigh muscle, treated rats demonstrated an increase in body weight, increased survivability, attenuated the hyperglycemic response as well as prevented the formation of ketoacidosis. For these reasons, the intraparenchymal injection of lentiviral vectors into the skeletal muscle to ectopically produce insulin may be an easy and therapeutic treatment modality for type 1 diabetes mellitus. |
| Author | Li, Mei Zi Kim, Seung Taik Oh, Tae Keun |
| Author_xml | – sequence: 1 givenname: Tae Keun surname: Oh fullname: Oh, Tae Keun – sequence: 2 givenname: Mei Zi surname: Li fullname: Li, Mei Zi – sequence: 3 givenname: Seung Taik surname: Kim fullname: Kim, Seung Taik email: stkim@chungbuk.ac.kr |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16171885$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/sj.gt.3301544 10.1038/emm.2003.64 10.1006/bbrc.2000.2936 10.1038/35044106 10.1016/0014-5793(92)81366-T 10.1006/mthe.2001.0299 10.1210/me.11.6.833 10.1073/pnas.93.16.8595 10.1089/10430349950016672 10.1073/pnas.92.8.3293 10.1677/jme.0.0110335 10.1073/pnas.80.4.1068 10.1128/JVI.71.9.6641-6649.1997 10.1038/nbt1297-1378 10.1016/S0041-1345(97)00305-9 10.1016/S0014-5793(01)02352-3 10.1055/s-2007-979108 10.1038/sj.gt.3301297 10.2337/diabetes.41.8.956 10.2337/diabetes.51.1.130 10.1002/(SICI)1521-2254(199905/06)1:3<186::AID-JGM33>3.0.CO;2-W 10.1128/JVI.74.16.7642-7645.2000 10.1056/NEJM200007273430401 10.1016/S0021-9258(18)63828-1 10.1016/S0014-5793(01)03146-5 10.1126/science.283.5402.682 |
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| Keywords | Insulin gene therapy Lentivirus Intramuscular injection |
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| References | Stewart, Taylor, Docherty, Bailey (bib21) 1993; 11 Kolodka, Finegold, Moss, Woo (bib2) 1995; 92 Short, Okada, Yamauchi, Pessin (bib4) 1998; 275 Morishita, Gibbons, Kaneda, Ogihara, Dzau (bib14) 2000; 273 Yanagita, Nakayama, Takeguchi (bib23) 1992; 311 Kawakami, Yamaoka, Hirochika, Yamashita, Itakura, Nakauchi (bib19) 1992; 41 Kasten-Jolly, Aubrey, Conti, Rosano, Ross, Freed (bib20) 1997; 29 Abai, Hobart, Barnhart (bib16) 1999; 10 Kon, Sivakumar, Teoh, Lok, Long (bib17) 1999; 1 Seppen, Barry, Klinkspoor, Katen, Lee, Garcia (bib24) 2000; 74 Nagamatsu, Nakamichi, Ohara-Imaizumi, Ozawa, Katahira, Watanabe (bib9) 2001; 509 Lipes, Cooper, Skelly, Rhodes, Boschetti, Weir (bib22) 1996; 93 Shapiro, Lakey, Ryan, Korbutt, Toth, Warnock (bib1) 2000; 343 Yin, Tang (bib18) 2000; 495 Miyoshi, Smith, Moiser, Berma, Torbett (bib26) 1999; 283 Dong, Altomonte, Morral, Meseck, Thung, Woo (bib7) 2002; 51 Blomer, Naldini, Kafri, Trono, Verma, Gage (bib25) 1997; 71 Sugiyama, Hattori, Tanaka, Isoda, Kleopoulos, Rosenfeld (bib10) 1997; 29 Chen, Meseck, Woo (bib5) 2001; 3 Shifrin, Auricchio, Yu, Wilson, Raper (bib8) 2001; 8 Lee, Kim, Kim, Shin, Yoon (bib11) 2000; 408 Kaneda, Iwai, Uchida (bib13) 1989; 264 Thule, Liu (bib6) 2000; 7 Muzzin, Eisensmith, Copeland, Woo (bib3) 1997; 11 Goldfine, German, Tseng, Wang, Bolaffi, Chen (bib15) 1997; 15 Nicolau, Le Pape, Soriano, Fargette, Juhel (bib12) 1983; 80 Park, Kim, Lee (bib27) 2003; 35 Muzzin (10.1016/j.diabres.2005.08.005_bib3) 1997; 11 Kasten-Jolly (10.1016/j.diabres.2005.08.005_bib20) 1997; 29 Kaneda (10.1016/j.diabres.2005.08.005_bib13) 1989; 264 Dong (10.1016/j.diabres.2005.08.005_bib7) 2002; 51 Shapiro (10.1016/j.diabres.2005.08.005_bib1) 2000; 343 Seppen (10.1016/j.diabres.2005.08.005_bib24) 2000; 74 Shifrin (10.1016/j.diabres.2005.08.005_bib8) 2001; 8 Nicolau (10.1016/j.diabres.2005.08.005_bib12) 1983; 80 Lee (10.1016/j.diabres.2005.08.005_bib11) 2000; 408 Chen (10.1016/j.diabres.2005.08.005_bib5) 2001; 3 Nagamatsu (10.1016/j.diabres.2005.08.005_bib9) 2001; 509 Goldfine (10.1016/j.diabres.2005.08.005_bib15) 1997; 15 Blomer (10.1016/j.diabres.2005.08.005_bib25) 1997; 71 Kawakami (10.1016/j.diabres.2005.08.005_bib19) 1992; 41 Short (10.1016/j.diabres.2005.08.005_bib4) 1998; 275 Yanagita (10.1016/j.diabres.2005.08.005_bib23) 1992; 311 Abai (10.1016/j.diabres.2005.08.005_bib16) 1999; 10 Park (10.1016/j.diabres.2005.08.005_bib27) 2003; 35 Morishita (10.1016/j.diabres.2005.08.005_bib14) 2000; 273 Miyoshi (10.1016/j.diabres.2005.08.005_bib26) 1999; 283 Kolodka (10.1016/j.diabres.2005.08.005_bib2) 1995; 92 Thule (10.1016/j.diabres.2005.08.005_bib6) 2000; 7 Sugiyama (10.1016/j.diabres.2005.08.005_bib10) 1997; 29 Kon (10.1016/j.diabres.2005.08.005_bib17) 1999; 1 Yin (10.1016/j.diabres.2005.08.005_bib18) 2000; 495 Stewart (10.1016/j.diabres.2005.08.005_bib21) 1993; 11 Lipes (10.1016/j.diabres.2005.08.005_bib22) 1996; 93 |
| References_xml | – volume: 311 start-page: 55 year: 1992 end-page: 59 ident: bib23 article-title: Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7 publication-title: FEBS Lett. – volume: 283 start-page: 682 year: 1999 end-page: 686 ident: bib26 article-title: Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors publication-title: Science – volume: 495 start-page: 16 year: 2000 end-page: 20 ident: bib18 article-title: Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo publication-title: FEBS Lett. – volume: 15 start-page: 1378 year: 1997 end-page: 1382 ident: bib15 article-title: The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract publication-title: Nat. Biotechol. – volume: 275 start-page: E748 year: 1998 end-page: E756 ident: bib4 article-title: Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice publication-title: Am. J. Physiol. – volume: 41 start-page: 956 year: 1992 end-page: 961 ident: bib19 article-title: Somatic gene therapy for diabetes with an immunological safety system for complete removal of transplanted cells publication-title: Diabetes – volume: 80 start-page: 1068 year: 1983 end-page: 1072 ident: bib12 article-title: In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 343 start-page: 230 year: 2000 end-page: 238 ident: bib1 article-title: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen publication-title: N. Engl. J. Med. – volume: 71 start-page: 6641 year: 1997 end-page: 6649 ident: bib25 article-title: Highly efficient and sustained gene transfer in adult neurons with a lentiviral vector publication-title: J. Virol. – volume: 51 start-page: 130 year: 2002 end-page: 138 ident: bib7 article-title: Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats publication-title: Diabetes – volume: 1 start-page: 186 year: 1999 end-page: 194 ident: bib17 article-title: Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus publication-title: J. Gene Med. – volume: 3 start-page: 584 year: 2001 end-page: 590 ident: bib5 article-title: Auto-regulated hepatic insulin gene expression in type 1 diabetic rats publication-title: Mol. Ther. – volume: 92 start-page: 3293 year: 1995 end-page: 3297 ident: bib2 article-title: Gene therapy for diabetes mellitus in rats by hepatic expression of insulin publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 29 start-page: 2216 year: 1997 end-page: 2218 ident: bib20 article-title: Reversal of hyperglycemia in diabetic NOD mice by human proinsulin gene therapy publication-title: Transplant. Proc. – volume: 408 start-page: 483 year: 2000 end-page: 488 ident: bib11 article-title: Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue publication-title: Nature – volume: 11 start-page: 833 year: 1997 end-page: 837 ident: bib3 article-title: Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats publication-title: Mol. Endocrinol. – volume: 264 start-page: 12126 year: 1989 end-page: 12129 ident: bib13 article-title: Introduction and expression of the human insulin gene in adult rat liver publication-title: J. Biol. Chem. – volume: 7 start-page: 1744 year: 2000 end-page: 1752 ident: bib6 article-title: Regulated hepatic insulin gene therapy of STZ-diabetic rats publication-title: Gene Ther. – volume: 11 start-page: 335 year: 1993 end-page: 341 ident: bib21 article-title: Insulin delivery by somatic gene therapy publication-title: J. Mol. Endocrinol. – volume: 93 start-page: 8595 year: 1996 end-page: 8600 ident: bib22 article-title: Insulin-secreting non-islet cells are resistant to autoimmune destruction publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 35 start-page: 494 year: 2003 end-page: 500 ident: bib27 article-title: Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice publication-title: Exp. Mol. Med. – volume: 8 start-page: 1480 year: 2001 end-page: 1489 ident: bib8 article-title: Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia publication-title: Gene Ther. – volume: 29 start-page: 599 year: 1997 end-page: 603 ident: bib10 article-title: Defective adeno-associated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice publication-title: Horm. Metab. Res. – volume: 509 start-page: 106 year: 2001 end-page: 110 ident: bib9 article-title: Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y)mice publication-title: FEBS Lett. – volume: 273 start-page: 666 year: 2000 end-page: 674 ident: bib14 article-title: Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose levels in diabetic mouse: a model of gene therapy publication-title: Biochem. Biophys. Res. Commun. – volume: 10 start-page: 2637 year: 1999 end-page: 2649 ident: bib16 article-title: Insulin delivery with plasmid DNA publication-title: Hum. Gene Ther. – volume: 74 start-page: 7642 year: 2000 end-page: 7645 ident: bib24 article-title: Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors publication-title: J. Virol. – volume: 8 start-page: 1480 year: 2001 ident: 10.1016/j.diabres.2005.08.005_bib8 article-title: Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia publication-title: Gene Ther. doi: 10.1038/sj.gt.3301544 – volume: 35 start-page: 494 year: 2003 ident: 10.1016/j.diabres.2005.08.005_bib27 article-title: Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice publication-title: Exp. Mol. Med. doi: 10.1038/emm.2003.64 – volume: 273 start-page: 666 year: 2000 ident: 10.1016/j.diabres.2005.08.005_bib14 article-title: Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose levels in diabetic mouse: a model of gene therapy publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2000.2936 – volume: 408 start-page: 483 year: 2000 ident: 10.1016/j.diabres.2005.08.005_bib11 article-title: Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue publication-title: Nature doi: 10.1038/35044106 – volume: 311 start-page: 55 year: 1992 ident: 10.1016/j.diabres.2005.08.005_bib23 article-title: Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7 publication-title: FEBS Lett. doi: 10.1016/0014-5793(92)81366-T – volume: 3 start-page: 584 year: 2001 ident: 10.1016/j.diabres.2005.08.005_bib5 article-title: Auto-regulated hepatic insulin gene expression in type 1 diabetic rats publication-title: Mol. Ther. doi: 10.1006/mthe.2001.0299 – volume: 11 start-page: 833 year: 1997 ident: 10.1016/j.diabres.2005.08.005_bib3 article-title: Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats publication-title: Mol. Endocrinol. doi: 10.1210/me.11.6.833 – volume: 93 start-page: 8595 year: 1996 ident: 10.1016/j.diabres.2005.08.005_bib22 article-title: Insulin-secreting non-islet cells are resistant to autoimmune destruction publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.93.16.8595 – volume: 10 start-page: 2637 year: 1999 ident: 10.1016/j.diabres.2005.08.005_bib16 article-title: Insulin delivery with plasmid DNA publication-title: Hum. Gene Ther. doi: 10.1089/10430349950016672 – volume: 92 start-page: 3293 year: 1995 ident: 10.1016/j.diabres.2005.08.005_bib2 article-title: Gene therapy for diabetes mellitus in rats by hepatic expression of insulin publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.92.8.3293 – volume: 11 start-page: 335 year: 1993 ident: 10.1016/j.diabres.2005.08.005_bib21 article-title: Insulin delivery by somatic gene therapy publication-title: J. Mol. Endocrinol. doi: 10.1677/jme.0.0110335 – volume: 80 start-page: 1068 year: 1983 ident: 10.1016/j.diabres.2005.08.005_bib12 article-title: In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.80.4.1068 – volume: 71 start-page: 6641 year: 1997 ident: 10.1016/j.diabres.2005.08.005_bib25 article-title: Highly efficient and sustained gene transfer in adult neurons with a lentiviral vector publication-title: J. Virol. doi: 10.1128/JVI.71.9.6641-6649.1997 – volume: 15 start-page: 1378 year: 1997 ident: 10.1016/j.diabres.2005.08.005_bib15 article-title: The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract publication-title: Nat. Biotechol. doi: 10.1038/nbt1297-1378 – volume: 29 start-page: 2216 year: 1997 ident: 10.1016/j.diabres.2005.08.005_bib20 article-title: Reversal of hyperglycemia in diabetic NOD mice by human proinsulin gene therapy publication-title: Transplant. Proc. doi: 10.1016/S0041-1345(97)00305-9 – volume: 495 start-page: 16 year: 2000 ident: 10.1016/j.diabres.2005.08.005_bib18 article-title: Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo publication-title: FEBS Lett. doi: 10.1016/S0014-5793(01)02352-3 – volume: 275 start-page: E748 year: 1998 ident: 10.1016/j.diabres.2005.08.005_bib4 article-title: Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice publication-title: Am. J. Physiol. – volume: 29 start-page: 599 year: 1997 ident: 10.1016/j.diabres.2005.08.005_bib10 article-title: Defective adeno-associated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice publication-title: Horm. Metab. Res. doi: 10.1055/s-2007-979108 – volume: 7 start-page: 1744 year: 2000 ident: 10.1016/j.diabres.2005.08.005_bib6 article-title: Regulated hepatic insulin gene therapy of STZ-diabetic rats publication-title: Gene Ther. doi: 10.1038/sj.gt.3301297 – volume: 41 start-page: 956 year: 1992 ident: 10.1016/j.diabres.2005.08.005_bib19 article-title: Somatic gene therapy for diabetes with an immunological safety system for complete removal of transplanted cells publication-title: Diabetes doi: 10.2337/diabetes.41.8.956 – volume: 51 start-page: 130 year: 2002 ident: 10.1016/j.diabres.2005.08.005_bib7 article-title: Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats publication-title: Diabetes doi: 10.2337/diabetes.51.1.130 – volume: 1 start-page: 186 year: 1999 ident: 10.1016/j.diabres.2005.08.005_bib17 article-title: Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus publication-title: J. Gene Med. doi: 10.1002/(SICI)1521-2254(199905/06)1:3<186::AID-JGM33>3.0.CO;2-W – volume: 74 start-page: 7642 year: 2000 ident: 10.1016/j.diabres.2005.08.005_bib24 article-title: Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors publication-title: J. Virol. doi: 10.1128/JVI.74.16.7642-7645.2000 – volume: 343 start-page: 230 year: 2000 ident: 10.1016/j.diabres.2005.08.005_bib1 article-title: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen publication-title: N. Engl. J. Med. doi: 10.1056/NEJM200007273430401 – volume: 264 start-page: 12126 year: 1989 ident: 10.1016/j.diabres.2005.08.005_bib13 article-title: Introduction and expression of the human insulin gene in adult rat liver publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)63828-1 – volume: 509 start-page: 106 year: 2001 ident: 10.1016/j.diabres.2005.08.005_bib9 article-title: Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y)mice publication-title: FEBS Lett. doi: 10.1016/S0014-5793(01)03146-5 – volume: 283 start-page: 682 year: 1999 ident: 10.1016/j.diabres.2005.08.005_bib26 article-title: Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors publication-title: Science doi: 10.1126/science.283.5402.682 |
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| SubjectTerms | Animals Cell Line Diabetes Mellitus, Experimental - drug therapy Genes, Reporter Genetic Therapy - methods Genetic Vectors Green Fluorescent Proteins - genetics HeLa Cells Humans Injections, Intramuscular Insulin - administration & dosage Insulin - genetics Insulin - therapeutic use Insulin gene therapy Intramuscular injection Lentivirus Lentivirus - genetics Male Mice Proinsulin - genetics Promoter Regions, Genetic Rats Rats, Inbred F344 |
| Title | Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene |
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