Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer

Aside from Gleason sum, few factors accurately identify the subset of prostate cancer patients at high risk for metastatic progression. We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. Epigenome-wide DNA methylation profiling was performe...

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Vydáno v:	Clinical cancer research Ročník 23; číslo 1; s. 311 - 319
Hlavní autoři:	Zhao, Shanshan, Geybels, Milan S, Leonardson, Amy, Rubicz, Rohina, Kolb, Suzanne, Yan, Qingxiang, Klotzle, Brandy, Bibikova, Marina, Hurtado-Coll, Antonio, Troyer, Dean, Lance, Raymond, Lin, Daniel W, Wright, Jonathan L, Ostrander, Elaine A, Fan, Jian-Bing, Feng, Ziding, Stanford, Janet L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2017
Témata:	Adult Aged Alleles Biomarkers, Tumor CpG Islands Disease Progression DNA Methylation Epigenesis, Genetic Epigenomics - methods Gene Expression Profiling Genome-Wide Association Study Humans Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Prostatic Neoplasms - mortality Prostatic Neoplasms - therapy Recurrence Reproducibility of Results ROC Curve
ISSN:	1557-3265
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