Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer

Aside from Gleason sum, few factors accurately identify the subset of prostate cancer patients at high risk for metastatic progression. We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. Epigenome-wide DNA methylation profiling was performe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research Jg. 23; H. 1; S. 311 - 319
Hauptverfasser:	Zhao, Shanshan, Geybels, Milan S, Leonardson, Amy, Rubicz, Rohina, Kolb, Suzanne, Yan, Qingxiang, Klotzle, Brandy, Bibikova, Marina, Hurtado-Coll, Antonio, Troyer, Dean, Lance, Raymond, Lin, Daniel W, Wright, Jonathan L, Ostrander, Elaine A, Fan, Jian-Bing, Feng, Ziding, Stanford, Janet L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2017
Schlagworte:	Adult Aged Alleles Biomarkers, Tumor CpG Islands Disease Progression DNA Methylation Epigenesis, Genetic Epigenomics - methods Gene Expression Profiling Genome-Wide Association Study Humans Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Prostatic Neoplasms - mortality Prostatic Neoplasms - therapy Recurrence Reproducibility of Results ROC Curve
ISSN:	1557-3265
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!