Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer

Circulating lncRNAs have been defined as a novel biomarker for non-small cell lung cancer (NSCLC), MALAT-1 was first identified lncRNA that was related to lung cancer metastasis. However, the relationship between exosomal lncRNAs and the diagnosis and prognosis of NSCLC was poorly understood. The ai...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 490; no. 2; pp. 406 - 414
Main Authors:	Zhang, Rui, Xia, Yuhong, Wang, Zhixin, Zheng, Jie, Chen, Yafei, Li, Xiaoli, Wang, Yu, Ming, Huaikun
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 19.08.2017
Subjects:	60 APPLIED LIFE SCIENCES APOPTOSIS BIOLOGICAL MARKERS biomarkers blood serum Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology CELL CYCLE Cell Line, Tumor Cell Movement CELL PROLIFERATION COLONY FORMATION DIAGNOSIS Diagnostic marker Exosomes Exosomes - genetics Exosomes - pathology flow cytometry Gene Expression Regulation, Neoplastic HEALING Humans IN VITRO in vitro studies Lung - pathology lung neoplasms Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - pathology LUNGS Lymphatic Metastasis - diagnosis Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology MALAT-1 METASTASES metastasis Migration neoplasm cells NEOPLASMS non-coding RNA Non-small cell lung cancer PATIENTS Prognosis Proliferation RNA RNA, Long Noncoding - blood RNA, Long Noncoding - genetics small interfering RNA TUMOR CELLS Up-Regulation WOUNDS Diagnostic marker Proliferation Exosomes Migration Non-small cell lung cancer MALAT-1
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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