Randomized Trial of Platelet-Transfusion Thresholds in Neonates

The rate of death or major bleeding was significantly higher among preterm infants with severe thrombocytopenia assigned to transfusions at higher platelet-count thresholds (50,000 per cubic millimeter) than among those assigned to lower thresholds (25,000 per cubic millimeter).

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Vydané v:The New England journal of medicine Ročník 380; číslo 3; s. 242 - 251
Hlavní autori: Curley, Anna, Stanworth, Simon J, Willoughby, Karen, Fustolo-Gunnink, Susanna F, Venkatesh, Vidheya, Hudson, Cara, Deary, Alison, Hodge, Renate, Hopkins, Valerie, Lopez Santamaria, Beatriz, Mora, Ana, Llewelyn, Charlotte, D’Amore, Angela, Khan, Rizwan, Onland, Wes, Lopriore, Enrico, Fijnvandraat, Karin, New, Helen, Clarke, Paul, Watts, Timothy
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Massachusetts Medical Society 17.01.2019
Predmet:
Age
Birth weight
Bleeding
Blood platelets
Death
Evidence-based medicine
Female
Gestational age
Health services
Hemorrhage
Hemorrhage - etiology
Hemorrhage - prevention & control
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - mortality
Infant, Premature, Diseases - therapy
Infants
Male
Medical research
Neonates
Newborn babies
Platelet Count
Platelet Transfusion
Platelets
Premature birth
R&D
Research & development
Thrombocytopenia
Thrombocytopenia - complications
Thrombocytopenia - mortality
Thrombocytopenia - therapy
United Kingdom > UK
Ireland
ISSN:0028-4793, 1533-4406, 1533-4406
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Popis
Shrnutí:The rate of death or major bleeding was significantly higher among preterm infants with severe thrombocytopenia assigned to transfusions at higher platelet-count thresholds (50,000 per cubic millimeter) than among those assigned to lower thresholds (25,000 per cubic millimeter).
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Feature-1
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ObjectType-Undefined-3
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1807320