A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel networ...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 212; no. 7; pp. 991 - 999
Main Authors:	Aspelund, Aleksanteri, Antila, Salli, Proulx, Steven T, Karlsen, Tine Veronica, Karaman, Sinem, Detmar, Michael, Wiig, Helge, Alitalo, Kari
Format:	Journal Article
Language:	English
Published:	United States 29.06.2015
Subjects:	Analysis of Variance Animals Brain - anatomy & histology Brain - metabolism Cerebrospinal Fluid - metabolism Extracellular Fluid - metabolism Fluorescent Antibody Technique Galactosides Green Fluorescent Proteins Image Processing, Computer-Assisted Indoles Lymph Nodes - metabolism Lymphatic System - anatomy & histology Lymphatic System - metabolism Macromolecular Substances - metabolism Mice Mice, Transgenic Microscopy, Confocal
ISSN:	1540-9538
Online Access:	Get more information
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