Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury

Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the adult central and peripheral nervous system. Since the 1950s, these factors have been extensively studied in traumatic inj...

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Vydané v:International journal of molecular sciences Ročník 18; číslo 3; s. 548
Hlavní autori: Keefe, Kathleen, Sheikh, Imran, Smith, George
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI 03.03.2017
Predmet:
Animals
Brain-Derived Neurotrophic Factor - metabolism
Humans
Molecular Targeted Therapy
Nerve Growth Factor - metabolism
Nerve Growth Factors - metabolism
Nerve Growth Factors - pharmacology
Nerve Growth Factors - therapeutic use
Nerve Regeneration - drug effects
Neural Pathways - drug effects
Neurons - drug effects
Neurons - metabolism
Neurotrophin 3 - metabolism
Protein Binding
Review
Signal Transduction - drug effects
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - etiology
Spinal Cord Injuries - metabolism
spinal cord injury
nerve growth factor
regeneration
neuroprotection
neurotrophic factors
plasticity
brain-derived neurotrophic factor
neurotrophin-3
ISSN:1422-0067, 1422-0067
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Popis
Shrnutí:Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the adult central and peripheral nervous system. Since the 1950s, these factors have been extensively studied in traumatic injury models. Here we review several members of the classical family of neurotrophins, the receptors they bind to, and their contribution to axonal regeneration and sprouting of sensory and motor pathways after spinal cord injury (SCI). We focus on nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), and their effects on populations of neurons within diverse spinal tracts. Understanding the cellular targets of neurotrophins and the responsiveness of specific neuronal populations will allow for the most efficient treatment strategies in the injured spinal cord.
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These authors contributed equally to this work.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms18030548