Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis

Neurodegeneration is thought to be the major cause of ongoing, irreversible disability in progressive stages of multiple sclerosis. Gamma-aminobutyric acid is the principle inhibitory neurotransmitter in the brain. The aims of this study were to investigate if gamma-aminobutyric acid levels (i) are...

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Bibliographic Details
Published in:	Brain (London, England : 1878) Vol. 138; no. Pt 9; p. 2584
Main Authors:	Cawley, Niamh, Solanky, Bhavana S, Muhlert, Nils, Tur, Carmen, Edden, Richard A E, Wheeler-Kingshott, Claudia A M, Miller, David H, Thompson, Alan J, Ciccarelli, Olga
Format:	Journal Article
Language:	English
Published:	England 01.09.2015
Subjects:	Adult Aspartic Acid Brain - metabolism Disability Evaluation Disabled Persons Female gamma-Aminobutyric Acid - metabolism Glutamic Acid Humans Magnetic Resonance Spectroscopy Male Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Neuropsychological Tests Severity of Illness Index disease progression MRI disability multiple sclerosis gamma-aminobutyric acid (GABA)
ISSN:	1460-2156, 1460-2156
Online Access:	Get more information
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