Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( Ig ) repertoires. The ubiquitin E3 ligase HUWE1 controls proliferation, DNA damage responses, and DNA repair, including the base excision repair (BER) pathway...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 13; p. 986863
Main Authors:	Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 09.01.2023
Subjects:	B-cell B-Lymphocytes Cell Differentiation - genetics development DNA Repair homeostasis HUWE1 immune responses Immunoglobulin Class Switching - genetics Immunology somatic hypermutation Somatic Hypermutation, Immunoglobulin homeostasis development somatic hypermutation B-cell HUWE1 class switch recombination immune responses
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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