Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages

An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic acid (SA) on most cell types. Here, we use struct...

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Veröffentlicht in:	Journal of virology Jg. 88; H. 8; S. 4047
Hauptverfasser:	Whittle, James R R, Wheatley, Adam K, Wu, Lan, Lingwood, Daniel, Kanekiyo, Masaru, Ma, Steven S, Narpala, Sandeep R, Yassine, Hadi M, Frank, Gregory M, Yewdell, Jonathan W, Ledgerwood, Julie E, Wei, Chih-Jen, McDermott, Adrian B, Graham, Barney S, Koup, Richard A, Nabel, Gary J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2014
Schlagworte:	Antibodies, Neutralizing - immunology Antibodies, Viral - immunology B-Lymphocytes - immunology Cross Reactions Flow Cytometry Hemagglutinin Glycoproteins, Influenza Virus - administration & dosage Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immunoglobulin G - genetics Immunoglobulin G - immunology Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Molecular Sequence Data
ISSN:	1098-5514, 1098-5514
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