Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques

Treatment of human immunodeficiency virus (HIV) infection with antiretroviral therapy (ART) has significantly improved prognosis. Unfortunately, interruption of ART almost invariably results in viral rebound, attributed to a pool of long-lived, latently infected cells. Based on their longevity and p...

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Bibliographic Details
Published in:	Journal of virology Vol. 90; no. 15; pp. 6699 - 6708
Main Authors:	Cartwright, Emily K, Palesch, David, Mavigner, Maud, Paiardini, Mirko, Chahroudi, Ann, Silvestri, Guido
Format:	Journal Article
Language:	English
Published:	United States 01.08.2016
Subjects:	Animals Anti-Retroviral Agents - therapeutic use CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology DNA, Viral - genetics Homeostasis - physiology Humans Immunologic Memory - drug effects Immunologic Memory - immunology Macaca mulatta Primate Diseases - drug therapy Primate Diseases - immunology Primate Diseases - virology Simian Acquired Immunodeficiency Syndrome - drug therapy Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus Stem Cells - drug effects Stem Cells - immunology Stem Cells - virology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology Viral Load Virus Replication - drug effects
ISSN:	1098-5514
Online Access:	Get more information
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