A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure

In a randomized trial, 294 patients with advanced heart failure were assigned to receive either a new centrifugal-flow pump or an axial-flow pump. At 6 months, the centrifugal-flow pump was associated with better outcomes. A scarcity of effective therapeutic options for advanced heart failure has le...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 376; no. 5; pp. 440 - 450
Main Authors: Mehra, Mandeep R, Naka, Yoshifumi, Uriel, Nir, Goldstein, Daniel J, Cleveland, Joseph C, Colombo, Paolo C, Walsh, Mary N, Milano, Carmelo A, Patel, Chetan B, Jorde, Ulrich P, Pagani, Francis D, Aaronson, Keith D, Dean, David A, McCants, Kelly, Itoh, Akinobu, Ewald, Gregory A, Horstmanshof, Douglas, Long, James W, Salerno, Christopher
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 02.02.2017
Subjects:
Adult
Aged
Aged, 80 and over
Clinical outcomes
Disease-Free Survival
Heart diseases
Heart failure
Heart Failure - mortality
Heart Failure - therapy
Heart-Assist Devices - adverse effects
Humans
Intention to Treat Analysis
Kaplan-Meier Estimate
Middle Aged
Motivation
Navigation behavior
Patients
Prosthesis Design
Prosthesis Failure
Quality of life
Stroke
Stroke - etiology
Surgeons
Survival
Thrombosis
Thrombosis - etiology
Transplantation
Transplants & implants
Ventricle
Young Adult
United States > US
ISSN:0028-4793, 1533-4406
Online Access:Get full text
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Description
Summary:In a randomized trial, 294 patients with advanced heart failure were assigned to receive either a new centrifugal-flow pump or an axial-flow pump. At 6 months, the centrifugal-flow pump was associated with better outcomes. A scarcity of effective therapeutic options for advanced heart failure has led to the development of durable mechanical circulatory support devices. Left ventricular assist devices, more accurately known as left ventricular assist systems, increase the rate of survival and improve quality of life among patients with advanced heart failure. However, these clinical benefits are balanced by an increased risk of infection, bleeding, neurologic events, and pump malfunction that is due principally to pump thrombosis. 1 , 2 As adoption of circulatory pumps has expanded, concerns about pump thrombosis have heightened. In 2013, two reports suggested that there has been an increase in . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1610426