Sarcopenia in patients with diabetes mellitus

Introduction: Diseases such as diabetes mellitus may be associated with adverse changes in body composition. Sarcopenia is characterized by a progressive and generalized loss of skeletal muscle mass and functionality. Aim: To investigate the relationship between type 2 diabetes mellitus (T2DM) and s...

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Vydáno v:Folia Medica Ročník 64; číslo 4; s. 596 - 601
Hlavní autoři: Dionyssiotis, Yannis, Athanassiou, Panagiotis, Papathanasiou, Jannis, Efstathopoulos, Efstathios, Prokopidis, Konstantinos, Trovas, Georgios, Kostoglou-Athanassiou, Ifigenia
Médium: Journal Article
Jazyk:angličtina
Vydáno: Bulgaria MEDICAL UNIVERSITY- PLOVDIV 31.08.2022
Pensoft Publishers
Témata:
Age
Aged
Aging
Body Composition
Body mass index
Demographics
Diabetes
diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Disease
elderly
Female
Females
Glucose
Humans
Hyperglycemia
Insulin resistance
Male
Males
Metabolic disorders
Metabolism
Muscle, Skeletal
Musculoskeletal system
Obesity
Prevalence
Retrospective Studies
Sarcopenia
Sarcopenia - complications
Sarcopenia - etiology
who
whole body DXA
diabetes mellitus
aging
elderly
sarcopenia
ISSN:0204-8043, 1314-2143, 1314-2143
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Shrnutí:Introduction: Diseases such as diabetes mellitus may be associated with adverse changes in body composition. Sarcopenia is characterized by a progressive and generalized loss of skeletal muscle mass and functionality. Aim: To investigate the relationship between type 2 diabetes mellitus (T2DM) and sarcopenia. Materials and methods: In a retrospective, non-randomized study, 35 T2DM patients, aged 20-80 years, were assessed for sarcopenia prevalence compared to controls (n=16). Appendicular skeletal mass (ASM) (kg) was measured, and sarcopenia was defined as SMI <7.0 and <5.7 kg/m2, in males and females, respectively, using the European Working Group on Sarcopenia in Elderly (EWGOSP) definition. Low physical performance was defined as a walking speed of <0.8 m/s. Results: Incidence of sarcopenia was significantly higher in T2DM patients vs. controls (27% vs. 20%, p=0.01) and elderly vs. young participants (40% vs. 12%, p<0.001), respectively. Walking velocity was significantly lower in T2DM patients compared to male and female controls (1.08±0.22 vs. 1.23±0.18 and 1.07±0.26 vs. 1.26±0.16, respectively, p<0.001,). Conclusions: A moderate prevalence of sarcopenia in patients with type 2 diabetes mellitus was observed, which appeared to increase significantly in older men. Finally, incidence of T2DM displayed decreased physical performance in both genders.
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ISSN:0204-8043
1314-2143
1314-2143
DOI:10.3897/folmed.64.e63530