Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of acyclovir

Valaciclovir is an oral prodrug of the antiherpetic agent acyclovir. An enzyme that hydrolyzes valaciclovir to acyclovir, valaciclovir hydrolase (VACVase), was purified from rat liver and characterized. VACVase was a basic (pI 9.4) protein associated with mitochondria. It was monomeric and had a mol...

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Vydané v:	The Journal of biological chemistry Ročník 270; číslo 26; s. 15827
Hlavní autori:	Burnette, T C, Harrington, J A, Reardon, J E, Merrill, B M, de Miranda, P
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 30.06.1995
Predmet:	Acyclovir - analogs & derivatives Acyclovir - metabolism Amino Acid Sequence Animals Antiviral Agents - metabolism Biotransformation Hydrolases - chemistry Hydrolases - isolation & purification Hydrolases - physiology Liver - enzymology Male Molecular Sequence Data Prodrugs - metabolism Rats Valacyclovir Valine - analogs & derivatives Valine - metabolism
ISSN:	0021-9258
On-line prístup:	Zistit podrobnosti o prístupe
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