Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of acyclovir

Valaciclovir is an oral prodrug of the antiherpetic agent acyclovir. An enzyme that hydrolyzes valaciclovir to acyclovir, valaciclovir hydrolase (VACVase), was purified from rat liver and characterized. VACVase was a basic (pI 9.4) protein associated with mitochondria. It was monomeric and had a mol...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry Jg. 270; H. 26; S. 15827
Hauptverfasser:	Burnette, T C, Harrington, J A, Reardon, J E, Merrill, B M, de Miranda, P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.06.1995
Schlagworte:	Acyclovir - analogs & derivatives Acyclovir - metabolism Amino Acid Sequence Animals Antiviral Agents - metabolism Biotransformation Hydrolases - chemistry Hydrolases - isolation & purification Hydrolases - physiology Liver - enzymology Male Molecular Sequence Data Prodrugs - metabolism Rats Valacyclovir Valine - analogs & derivatives Valine - metabolism
ISSN:	0021-9258
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!