A wireless optogenetic setup in freely moving mice for evaluation of cortical spreading depolarization in a chronic disease model
Spreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of...
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| Vydáno v: | Journal of neuroscience methods Ročník 415; s. 110364 |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Netherlands
Elsevier B.V
01.03.2025
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| ISSN: | 0165-0270, 1872-678X, 1872-678X |
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| Abstract | Spreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of methodological limitations between clinical and experimental approaches focusing on short-term effects. Moreover, usage of highly invasive SD triggers has put into question to what extent SDs themselves or the induction method had caused emergence of tissue damage.
To overcome this gap, we here show the successful realization of an experimental approach for long-term SD induction in a wireless setup of minimal invasive optogenetic stimulation in freely behaving mice.
The proposed method allows for reliable SD induction over the course of three weeks. SD characteristics induced with the wireless setup were comparable to SDs elicited by KCl or cable-bound optogenetic systems. Immunohistological analysis of c-Fos expression revealed neuronal depolarization across the stimulated hemisphere, whereas TUNEL staining revealed no stimulation related apoptosis.
Optogenetic SD induction so far relied on cable- or fiber-bound systems which restrict experimental possibilities. The proposed model relies on wireless stimulation that allows SD induction in the home cage. In contrast to existing systems, the wireless setup also allows cage enrichment and group housing, therefore allowing behavioral analyses.
This experimental setup has excellent potential to investigate the question of possible long-term SD effects in mouse models of different acute pathologies like traumatic brain injury or migraine.
•Realization of a wireless optogenetic setup for spreading depolarization induction.•Wireless approach allows long-term experiments in freely moving mice.•Optogenetic induction method is minimally invasive, as proven by apoptosis marker.•Setup has potential to be used in various mouse models of acute brain pathologies.•Study of late spreading depolarizations closes translational gap to clinical data. |
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| AbstractList | Spreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of methodological limitations between clinical and experimental approaches focusing on short-term effects. Moreover, usage of highly invasive SD triggers has put into question to what extent SDs themselves or the induction method had caused emergence of tissue damage.
To overcome this gap, we here show the successful realization of an experimental approach for long-term SD induction in a wireless setup of minimal invasive optogenetic stimulation in freely behaving mice.
The proposed method allows for reliable SD induction over the course of three weeks. SD characteristics induced with the wireless setup were comparable to SDs elicited by KCl or cable-bound optogenetic systems. Immunohistological analysis of c-Fos expression revealed neuronal depolarization across the stimulated hemisphere, whereas TUNEL staining revealed no stimulation related apoptosis.
Optogenetic SD induction so far relied on cable- or fiber-bound systems which restrict experimental possibilities. The proposed model relies on wireless stimulation that allows SD induction in the home cage. In contrast to existing systems, the wireless setup also allows cage enrichment and group housing, therefore allowing behavioral analyses.
This experimental setup has excellent potential to investigate the question of possible long-term SD effects in mouse models of different acute pathologies like traumatic brain injury or migraine.
•Realization of a wireless optogenetic setup for spreading depolarization induction.•Wireless approach allows long-term experiments in freely moving mice.•Optogenetic induction method is minimally invasive, as proven by apoptosis marker.•Setup has potential to be used in various mouse models of acute brain pathologies.•Study of late spreading depolarizations closes translational gap to clinical data. Spreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of methodological limitations between clinical and experimental approaches focusing on short-term effects. Moreover, usage of highly invasive SD triggers has put into question to what extent SDs themselves or the induction method had caused emergence of tissue damage. To overcome this gap, we here show the successful realization of an experimental approach for long-term SD induction in a wireless setup of minimal invasive optogenetic stimulation in freely behaving mice. The proposed method allows for reliable SD induction over the course of three weeks. SD characteristics induced with the wireless setup were comparable to SDs elicited by KCl or cable-bound optogenetic systems. Immunohistological analysis of c-Fos expression revealed neuronal depolarization across the stimulated hemisphere, whereas TUNEL staining revealed no stimulation related apoptosis. Optogenetic SD induction so far relied on cable- or fiber-bound systems which restrict experimental possibilities. The proposed model relies on wireless stimulation that allows SD induction in the home cage. In contrast to existing systems, the wireless setup also allows cage enrichment and group housing, therefore allowing behavioral analyses. This experimental setup has excellent potential to investigate the question of possible long-term SD effects in mouse models of different acute pathologies like traumatic brain injury or migraine. Spreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of methodological limitations between clinical and experimental approaches focusing on short-term effects. Moreover, usage of highly invasive SD triggers has put into question to what extent SDs themselves or the induction method had caused emergence of tissue damage.BACKGROUNDSpreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of methodological limitations between clinical and experimental approaches focusing on short-term effects. Moreover, usage of highly invasive SD triggers has put into question to what extent SDs themselves or the induction method had caused emergence of tissue damage.To overcome this gap, we here show the successful realization of an experimental approach for long-term SD induction in a wireless setup of minimal invasive optogenetic stimulation in freely behaving mice.NEW METHODTo overcome this gap, we here show the successful realization of an experimental approach for long-term SD induction in a wireless setup of minimal invasive optogenetic stimulation in freely behaving mice.The proposed method allows for reliable SD induction over the course of three weeks. SD characteristics induced with the wireless setup were comparable to SDs elicited by KCl or cable-bound optogenetic systems. Immunohistological analysis of c-Fos expression revealed neuronal depolarization across the stimulated hemisphere, whereas TUNEL staining revealed no stimulation related apoptosis.RESULTSThe proposed method allows for reliable SD induction over the course of three weeks. SD characteristics induced with the wireless setup were comparable to SDs elicited by KCl or cable-bound optogenetic systems. Immunohistological analysis of c-Fos expression revealed neuronal depolarization across the stimulated hemisphere, whereas TUNEL staining revealed no stimulation related apoptosis.Optogenetic SD induction so far relied on cable- or fiber-bound systems which restrict experimental possibilities. The proposed model relies on wireless stimulation that allows SD induction in the home cage. In contrast to existing systems, the wireless setup also allows cage enrichment and group housing, therefore allowing behavioral analyses.COMPARISON WITH EXISTING METHODSOptogenetic SD induction so far relied on cable- or fiber-bound systems which restrict experimental possibilities. The proposed model relies on wireless stimulation that allows SD induction in the home cage. In contrast to existing systems, the wireless setup also allows cage enrichment and group housing, therefore allowing behavioral analyses.This experimental setup has excellent potential to investigate the question of possible long-term SD effects in mouse models of different acute pathologies like traumatic brain injury or migraine.CONCLUSIONThis experimental setup has excellent potential to investigate the question of possible long-term SD effects in mouse models of different acute pathologies like traumatic brain injury or migraine. |
| ArticleNumber | 110364 |
| Author | Köhne, Annika Helgers, Simeon O.A. Said, Maryam Kewitz, Bettina Sánchez-Porras, Renan Dömer, Patrick Oppermann, Viktoria Meinert, Franziska Haupt, Rieke M. Woitzik, Johannes |
| Author_xml | – sequence: 1 givenname: Annika surname: Köhne fullname: Köhne, Annika organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 2 givenname: Simeon O.A. surname: Helgers fullname: Helgers, Simeon O.A. organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 3 givenname: Bettina surname: Kewitz fullname: Kewitz, Bettina organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 4 givenname: Rieke M. surname: Haupt fullname: Haupt, Rieke M. organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 5 givenname: Viktoria surname: Oppermann fullname: Oppermann, Viktoria organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 6 givenname: Franziska surname: Meinert fullname: Meinert, Franziska organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 7 givenname: Renan surname: Sánchez-Porras fullname: Sánchez-Porras, Renan organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 8 givenname: Maryam surname: Said fullname: Said, Maryam organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 9 givenname: Johannes surname: Woitzik fullname: Woitzik, Johannes organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany – sequence: 10 givenname: Patrick surname: Dömer fullname: Dömer, Patrick email: patrick.doemer@uni-oldenburg.de organization: Department of Neurosurgery, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany |
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| Keywords | Stroke Optogenetic implant Internal carotid artery occlusion Chronic cerebral hypoperfusion Minimal invasive Spreading depression Wireless optogenetics |
| Language | English |
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| SubjectTerms | Animals Chronic cerebral hypoperfusion Chronic Disease Cortical Spreading Depression - physiology Disease Models, Animal Internal carotid artery occlusion Male Mice Mice, Inbred C57BL Mice, Transgenic Minimal invasive Neurons - physiology Optogenetic implant Optogenetics - instrumentation Optogenetics - methods Proto-Oncogene Proteins c-fos - metabolism Spreading depression Stroke Wireless optogenetics Wireless Technology - instrumentation |
| Title | A wireless optogenetic setup in freely moving mice for evaluation of cortical spreading depolarization in a chronic disease model |
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