Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments
To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision. One hundred thirty-nine consecutive subjects were imaged (3 x 3.4-mm diameter circular...
Uloženo v:
| Vydáno v: | Investigative ophthalmology & visual science Ročník 46; číslo 4; s. 1280 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.04.2005
|
| Témata: | |
| ISSN: | 0146-0404 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision.
One hundred thirty-nine consecutive subjects were imaged (3 x 3.4-mm diameter circular scans) on the same day with each instrument. Thirty-five patients were excluded due to poor-quality images. RNFL thicknesses measured by the two instruments were compared, and receiver operating characteristic (ROC) curves were used to determine diagnostic precision.
A randomly selected eye of each of 104 participants (28 with open-angle glaucoma, 40 with suspected glaucoma, and 36 healthy subjects) was analyzed. RNFL thickness measurements generally were thicker with OCT 2000 than with Stratus OCT. The difference in global RNFL thickness between instruments was within 20 microm in 66 (65%) of subjects and within 10 microm (the instrument's limit of resolution) in 25 (25%) subjects. Application of a correction factor to OCT 2000 measurements predicted Stratus OCT RNFL thickness within 10 microm of the observed measurement in 75% of the eyes. For both instruments, highest ROC curve areas (better discrimination between glaucomatous and normal eyes) were found in the inferior sector. Discrimination using global RNFL thickness was better with Stratus OCT than OCT 2000 (P = 0.043).
RNFL thickness measurements measured by OCT 2000 can be approximated to measurements made by Stratus OCT using correction factors calculated by this study. However, there remains considerable variability that exceeds the limits of resolution afforded by the instruments themselves. Therefore comparisons between instruments using these approximations should be interpreted with caution. |
|---|---|
| AbstractList | To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision.
One hundred thirty-nine consecutive subjects were imaged (3 x 3.4-mm diameter circular scans) on the same day with each instrument. Thirty-five patients were excluded due to poor-quality images. RNFL thicknesses measured by the two instruments were compared, and receiver operating characteristic (ROC) curves were used to determine diagnostic precision.
A randomly selected eye of each of 104 participants (28 with open-angle glaucoma, 40 with suspected glaucoma, and 36 healthy subjects) was analyzed. RNFL thickness measurements generally were thicker with OCT 2000 than with Stratus OCT. The difference in global RNFL thickness between instruments was within 20 microm in 66 (65%) of subjects and within 10 microm (the instrument's limit of resolution) in 25 (25%) subjects. Application of a correction factor to OCT 2000 measurements predicted Stratus OCT RNFL thickness within 10 microm of the observed measurement in 75% of the eyes. For both instruments, highest ROC curve areas (better discrimination between glaucomatous and normal eyes) were found in the inferior sector. Discrimination using global RNFL thickness was better with Stratus OCT than OCT 2000 (P = 0.043).
RNFL thickness measurements measured by OCT 2000 can be approximated to measurements made by Stratus OCT using correction factors calculated by this study. However, there remains considerable variability that exceeds the limits of resolution afforded by the instruments themselves. Therefore comparisons between instruments using these approximations should be interpreted with caution. To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision.PURPOSETo compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision.One hundred thirty-nine consecutive subjects were imaged (3 x 3.4-mm diameter circular scans) on the same day with each instrument. Thirty-five patients were excluded due to poor-quality images. RNFL thicknesses measured by the two instruments were compared, and receiver operating characteristic (ROC) curves were used to determine diagnostic precision.METHODSOne hundred thirty-nine consecutive subjects were imaged (3 x 3.4-mm diameter circular scans) on the same day with each instrument. Thirty-five patients were excluded due to poor-quality images. RNFL thicknesses measured by the two instruments were compared, and receiver operating characteristic (ROC) curves were used to determine diagnostic precision.A randomly selected eye of each of 104 participants (28 with open-angle glaucoma, 40 with suspected glaucoma, and 36 healthy subjects) was analyzed. RNFL thickness measurements generally were thicker with OCT 2000 than with Stratus OCT. The difference in global RNFL thickness between instruments was within 20 microm in 66 (65%) of subjects and within 10 microm (the instrument's limit of resolution) in 25 (25%) subjects. Application of a correction factor to OCT 2000 measurements predicted Stratus OCT RNFL thickness within 10 microm of the observed measurement in 75% of the eyes. For both instruments, highest ROC curve areas (better discrimination between glaucomatous and normal eyes) were found in the inferior sector. Discrimination using global RNFL thickness was better with Stratus OCT than OCT 2000 (P = 0.043).RESULTSA randomly selected eye of each of 104 participants (28 with open-angle glaucoma, 40 with suspected glaucoma, and 36 healthy subjects) was analyzed. RNFL thickness measurements generally were thicker with OCT 2000 than with Stratus OCT. The difference in global RNFL thickness between instruments was within 20 microm in 66 (65%) of subjects and within 10 microm (the instrument's limit of resolution) in 25 (25%) subjects. Application of a correction factor to OCT 2000 measurements predicted Stratus OCT RNFL thickness within 10 microm of the observed measurement in 75% of the eyes. For both instruments, highest ROC curve areas (better discrimination between glaucomatous and normal eyes) were found in the inferior sector. Discrimination using global RNFL thickness was better with Stratus OCT than OCT 2000 (P = 0.043).RNFL thickness measurements measured by OCT 2000 can be approximated to measurements made by Stratus OCT using correction factors calculated by this study. However, there remains considerable variability that exceeds the limits of resolution afforded by the instruments themselves. Therefore comparisons between instruments using these approximations should be interpreted with caution.CONCLUSIONSRNFL thickness measurements measured by OCT 2000 can be approximated to measurements made by Stratus OCT using correction factors calculated by this study. However, there remains considerable variability that exceeds the limits of resolution afforded by the instruments themselves. Therefore comparisons between instruments using these approximations should be interpreted with caution. |
| Author | Bourne, Rupert R A Bowd, Christopher Jahanbakhsh, Keyvan Zangwill, Linda M Medeiros, Felipe A Weinreb, Robert N |
| Author_xml | – sequence: 1 givenname: Rupert R A surname: Bourne fullname: Bourne, Rupert R A email: weinreb@eyecenter.ucsd.edu organization: Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA. weinreb@eyecenter.ucsd.edu – sequence: 2 givenname: Felipe A surname: Medeiros fullname: Medeiros, Felipe A – sequence: 3 givenname: Christopher surname: Bowd fullname: Bowd, Christopher – sequence: 4 givenname: Keyvan surname: Jahanbakhsh fullname: Jahanbakhsh, Keyvan – sequence: 5 givenname: Linda M surname: Zangwill fullname: Zangwill, Linda M – sequence: 6 givenname: Robert N surname: Weinreb fullname: Weinreb, Robert N |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15790891$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kLtPwzAYxD0U0QdszMgTW8rnxHmNqOIlVWKBOXLcz8QQ28F2KuW_J0BZ7pbfnXS3JgvrLBJyxWDLWFHeancMW-AJA4AFWQHjRQIc-JKsQ_gASBlL4ZwsWV7WUNVsRczOmUF40epex4k6RT1GbUVPLfojUqVb9LQX06yx0_LTYgjUoAijR4M2hp-MG6KWc0a6Dj1aiTQ64969GLqJahuiH3_ZC3KmRB_w8uQb8vZw_7p7SvYvj8-7u30iOStiIiTjuVKYthVKhTUHqSqFVcYrlkkAmWcgJBS1yGSNB5nlAtKqZcDKVol544bc_PUO3n2NGGJjdJDY98KiG0NTlHkOVZHO4PUJHFuDh2bw2gg_Nf8Hpd-K22sU |
| CitedBy_id | crossref_primary_10_1038_nrdp_2016_67 crossref_primary_10_1007_s00417_009_1241_0 crossref_primary_10_3928_15428877_20120524_01 crossref_primary_10_1016_j_ophtha_2008_12_032 crossref_primary_10_1016_j_ajo_2006_05_004 crossref_primary_10_1117_1_3119103 crossref_primary_10_1038_eye_2010_178 crossref_primary_10_1097_IJG_0b013e31817eee20 crossref_primary_10_1364_OE_18_024595 crossref_primary_10_1016_j_ophtha_2007_07_005 crossref_primary_10_1038_sj_eye_6702182 crossref_primary_10_3928_01913913_20100719_05 crossref_primary_10_1364_OPEX_13_009480 crossref_primary_10_1586_eop_10_33 crossref_primary_10_1007_s00417_011_1811_9 crossref_primary_10_1016_j_ajo_2009_05_030 crossref_primary_10_1016_j_ophtha_2010_01_046 crossref_primary_10_1097_IJG_0b013e3181bdb55d crossref_primary_10_1097_IJG_0b013e3181a98cfa crossref_primary_10_1109_TMI_2011_2109962 crossref_primary_10_3109_08820538_2012_760626 crossref_primary_10_1016_j_ophtha_2006_10_061 crossref_primary_10_1016_j_survophthal_2008_08_003 crossref_primary_10_15406_aovs_2017_07_00227 crossref_primary_10_1117_1_3171943 crossref_primary_10_1038_sj_eye_6702654 crossref_primary_10_1016_S0929_6646_08_60180_1 crossref_primary_10_1038_eye_2012_115 crossref_primary_10_3109_02713683_2014_952828 crossref_primary_10_1016_j_ajo_2006_04_053 crossref_primary_10_1371_journal_pone_0190621 crossref_primary_10_1111_j_1463_5224_2007_00532_x crossref_primary_10_1038_eye_2010_187 crossref_primary_10_3928_15428877_20110603_05 crossref_primary_10_1016_j_ophtha_2006_11_036 crossref_primary_10_1016_j_ophtha_2010_06_036 crossref_primary_10_1097_IJG_0b013e31811243b4 crossref_primary_10_1097_IJG_0b013e31814b9817 crossref_primary_10_1016_j_ophtha_2007_02_012 crossref_primary_10_1097_IJG_0000000000000363 crossref_primary_10_1097_IJG_0b013e3181c4b0c7 crossref_primary_10_1097_IJG_0b013e3180391a72 crossref_primary_10_1007_s10384_008_0538_6 crossref_primary_10_1016_j_ophtha_2006_01_036 crossref_primary_10_1016_j_ajo_2007_07_010 crossref_primary_10_1038_eye_2010_66 crossref_primary_10_1177_112067211002000303 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1167/iovs.04-1000 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| ExternalDocumentID | 15790891 |
| Genre | Research Support, U.S. Gov't, P.H.S Comparative Study Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NEI NIH HHS grantid: EY11008 – fundername: NEI NIH HHS grantid: R01 EY011008 |
| GroupedDBID | --- .55 .GJ 18M 2WC 34G 39C 53G 5GY 5RE ACGFO ACNCT ADBBV AENEX AFFNX AFOSN AI. ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P GROUPED_DOAJ GX1 N9A NPM OK1 P2P RPM SJN TR2 TRV VH1 W8F WH7 WOQ WOW X7M ZGI ZXP 7X8 |
| ID | FETCH-LOGICAL-c416t-ac145ffe2b8ecfe940cf8fe834813c00c530ac069a3c9edc35a028b1017bfa112 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 77 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000227908900025&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0146-0404 |
| IngestDate | Fri Sep 05 12:02:15 EDT 2025 Fri May 30 10:49:25 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c416t-ac145ffe2b8ecfe940cf8fe834813c00c530ac069a3c9edc35a028b1017bfa112 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 15790891 |
| PQID | 67550862 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_67550862 pubmed_primary_15790891 |
| PublicationCentury | 2000 |
| PublicationDate | 2005-04-01 |
| PublicationDateYYYYMMDD | 2005-04-01 |
| PublicationDate_xml | – month: 04 year: 2005 text: 2005-04-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Investigative ophthalmology & visual science |
| PublicationTitleAlternate | Invest Ophthalmol Vis Sci |
| PublicationYear | 2005 |
| SSID | ssj0021120 |
| Score | 2.1031318 |
| Snippet | To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1280 |
| SubjectTerms | Aged Cross-Sectional Studies Diagnostic Techniques, Ophthalmological Female Glaucoma, Open-Angle - diagnosis Humans Male Middle Aged Nerve Fibers - pathology Ocular Hypertension - diagnosis Optic Nerve Diseases - diagnosis Reproducibility of Results Retinal Ganglion Cells - pathology ROC Curve Tomography, Optical Coherence - methods |
| Title | Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/15790891 https://www.proquest.com/docview/67550862 |
| Volume | 46 |
| WOSCitedRecordID | wos000227908900025&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwED4VihAL70d5emA1deo4DwkJIUTFQKsOgLpFjmOLCpoUUirx7_E5CUyIgcVTToou58tn33ffAZzzNAx16GVUsoxTXyhGIy4DGmRCBZoHSjpW5dN9OBxG43E8asFl0wuDtMomJ7pEnRUK78i7FtgKhN9XszeKM6OwtloP0FiCNrdABgld4fi7hmBPNpUoo80F1Iaq39Deg7A7KRblBQr2McZ-h5buF9Pf-N_LbcJ6DS3JdRULW9DS-TasDuri-Q5Mbyqlb0eH_SSFIdjBiCY50h6JQfIIeZUWhBNkwb9gFiTTn0vEEm2Kmbv9Jqp4rjoFybyY1rrXZOL0aN2zu_DYv324uaP1tAWqLCibU6k8Xxije2mkldGxz5SJjI6wU5crxpTgTCoWxJKrWGeKC2mxSYpbOjXSOnsPlvMi1wdAZOZboClTbc92vpYs8kUspFF2yTyuex04a9yY2GjGEoXMdfFRJo0jO7BffYlkVoluJJ4IsUTpHf5pewRrTl_V0WuOoW3sPtYnsKIW80n5fuqCxK7D0eALrwfK9g |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparability+of+retinal+nerve+fiber+layer+thickness+measurements+of+optical+coherence+tomography+instruments&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.au=Bourne%2C+Rupert+R+A&rft.au=Medeiros%2C+Felipe+A&rft.au=Bowd%2C+Christopher&rft.au=Jahanbakhsh%2C+Keyvan&rft.date=2005-04-01&rft.issn=0146-0404&rft.volume=46&rft.issue=4&rft.spage=1280&rft_id=info:doi/10.1167%2Fiovs.04-1000&rft_id=info%3Apmid%2F15790891&rft_id=info%3Apmid%2F15790891&rft.externalDocID=15790891 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0146-0404&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0146-0404&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0146-0404&client=summon |