The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

The nature of the inflammatory response in the MS brain is poorly defined. Machado-Santos et al. report that chronic inflammation is dominated by tissue resident CD8+ T-cells and CD20+ B-cells, which are activated in lesions with demyelinating or neurodegenerative activity. Abstract Multiple scleros...

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Bibliographic Details
Published in:	Brain (London, England : 1878) Vol. 141; no. 7; pp. 2066 - 2082
Main Authors:	Machado-Santos, Joana, Saji, Etsuji, Tröscher, Anna R, Paunovic, Manuela, Liblau, Roland, Gabriely, Galina, Bien, Christian G, Bauer, Jan, Lassmann, Hans
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.07.2018
Subjects:	Adult Aged B-Lymphocytes - immunology B-Lymphocytes - physiology Brain - pathology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - physiology Demyelinating Diseases - pathology Encephalitis - metabolism Encephalitis - pathology Female Humans Inflammation - immunology Inflammation - metabolism Inflammation - pathology Lymphocytes - immunology Lymphocytes - physiology Male Middle Aged Multiple Sclerosis - immunology Multiple Sclerosis - pathology Phenotype brain lesions B cells T cells multiple sclerosis immune activation
ISSN:	0006-8950, 1460-2156, 1460-2156
Online Access:	Get full text
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