Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review

The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analys...

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Veröffentlicht in:CNS spectrums Jg. 27; H. 3; S. 298 - 308
Hauptverfasser: Palagini, Laura, Geoffroy, Pierre A., Miniati, Mario, Perugi, Giulio, Biggio, Giovanni, Marazziti, Donatella, Riemann, Dieter
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York, USA Cambridge University Press 01.06.2022
Schlagworte:
Bipolar disorder
Case reports
Circadian rhythm
Emotional disorders
Humans
Hypotheses
Insomnia
Mood Disorders
Neurodegeneration
Neurotoxicity
Oxidative stress
Physiology
Proteins
Public health
Review
Sleep - physiology
Sleep deprivation
Sleep Initiation and Maintenance Disorders
Sleep Wake Disorders
Suicides & suicide attempts
Systematic review
neurodegeneration
sleep loss
Insomnia
neuroprogression
mood disorders
circadian sleep alterations
ISSN:1092-8529, 2165-6509
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Abstract The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase electronic databases for literature related to mood disorders, sleep disturbances, and neurodegenerative/neuroprogressive processes in relation to (1) neuroinflammation, (2) activation of the stress system, (3) oxidative stress, (4) accumulation of neurotoxic proteins, and (5) neuroprotection deficit. Seventy articles were collectively selected and analyzed. Experimental and clinical studies revealed that insomnia, conditions of sleep loss, and altered circadian sleep may favor neurodegeneration and neuroprogression in mood disorders. These sleep disturbances may induce a state of chronic inflammation by enhancing neuroinflammation, both directly and indirectly, via microglia and astrocytes activation. They may act as neurobiological stressors that by over-activating the stress system may negatively influence neural plasticity causing neuronal damage. In addition, sleep disturbances may favor the accumulation of neurotoxic proteins, favor oxidative stress, and a deficit in neuroprotection hence contributing to neurodegeneration and neuroprogression. Targeting sleep disturbances in the clinical practice may hold a neuroprotective value for mood disorders.
AbstractList The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase electronic databases for literature related to mood disorders, sleep disturbances, and neurodegenerative/neuroprogressive processes in relation to (1) neuroinflammation, (2) activation of the stress system, (3) oxidative stress, (4) accumulation of neurotoxic proteins, and (5) neuroprotection deficit. Seventy articles were collectively selected and analyzed. Experimental and clinical studies revealed that insomnia, conditions of sleep loss, and altered circadian sleep may favor neurodegeneration and neuroprogression in mood disorders. These sleep disturbances may induce a state of chronic inflammation by enhancing neuroinflammation, both directly and indirectly, via microglia and astrocytes activation. They may act as neurobiological stressors that by over-activating the stress system may negatively influence neural plasticity causing neuronal damage. In addition, sleep disturbances may favor the accumulation of neurotoxic proteins, favor oxidative stress, and a deficit in neuroprotection hence contributing to neurodegeneration and neuroprogression. Targeting sleep disturbances in the clinical practice may hold a neuroprotective value for mood disorders.
The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase electronic databases for literature related to mood disorders, sleep disturbances, and neurodegenerative/neuroprogressive processes in relation to (1) neuroinflammation, (2) activation of the stress system, (3) oxidative stress, (4) accumulation of neurotoxic proteins, and (5) neuroprotection deficit. Seventy articles were collectively selected and analyzed. Experimental and clinical studies revealed that insomnia, conditions of sleep loss, and altered circadian sleep may favor neurodegeneration and neuroprogression in mood disorders. These sleep disturbances may induce a state of chronic inflammation by enhancing neuroinflammation, both directly and indirectly, via microglia and astrocytes activation. They may act as neurobiological stressors that by over-activating the stress system may negatively influence neural plasticity causing neuronal damage. In addition, sleep disturbances may favor the accumulation of neurotoxic proteins, favor oxidative stress, and a deficit in neuroprotection hence contributing to neurodegeneration and neuroprogression. Targeting sleep disturbances in the clinical practice may hold a neuroprotective value for mood disorders.The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase electronic databases for literature related to mood disorders, sleep disturbances, and neurodegenerative/neuroprogressive processes in relation to (1) neuroinflammation, (2) activation of the stress system, (3) oxidative stress, (4) accumulation of neurotoxic proteins, and (5) neuroprotection deficit. Seventy articles were collectively selected and analyzed. Experimental and clinical studies revealed that insomnia, conditions of sleep loss, and altered circadian sleep may favor neurodegeneration and neuroprogression in mood disorders. These sleep disturbances may induce a state of chronic inflammation by enhancing neuroinflammation, both directly and indirectly, via microglia and astrocytes activation. They may act as neurobiological stressors that by over-activating the stress system may negatively influence neural plasticity causing neuronal damage. In addition, sleep disturbances may favor the accumulation of neurotoxic proteins, favor oxidative stress, and a deficit in neuroprotection hence contributing to neurodegeneration and neuroprogression. Targeting sleep disturbances in the clinical practice may hold a neuroprotective value for mood disorders.
Author Palagini, Laura
Marazziti, Donatella
Riemann, Dieter
Biggio, Giovanni
Geoffroy, Pierre A.
Perugi, Giulio
Miniati, Mario
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  orcidid: 0000-0003-1676-629X
  surname: Palagini
  fullname: Palagini, Laura
  email: lpalagini@tiscali.it
  organization: Department of Experimental and Clinic Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy
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  givenname: Pierre A.
  orcidid: 0000-0001-9121-209X
  surname: Geoffroy
  fullname: Geoffroy, Pierre A.
  organization: Département de psychiatrie et d’addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hopital Bichat - Claude Bernard, F-75018 Paris, France
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  givenname: Mario
  orcidid: 0000-0001-7536-9927
  surname: Miniati
  fullname: Miniati, Mario
  organization: Department of Experimental and Clinic Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy
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  givenname: Giulio
  surname: Perugi
  fullname: Perugi, Giulio
  organization: Department of Experimental and Clinic Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy
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  surname: Biggio
  fullname: Biggio, Giovanni
  organization: Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
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  surname: Marazziti
  fullname: Marazziti, Donatella
  organization: Department of Experimental and Clinic Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy
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  givenname: Dieter
  surname: Riemann
  fullname: Riemann, Dieter
  organization: Department of Psychiatry and Psychotherapy, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33427150$$D View this record in MEDLINE/PubMed
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Copyright The Author(s), 2021. Published by Cambridge University Press
The Author(s), 2021. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s), 2021. Published by Cambridge University Press
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Issue 3
Keywords neurodegeneration
sleep loss
Insomnia
neuroprogression
mood disorders
circadian sleep alterations
Language English
License http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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OpenAccessLink https://www.cambridge.org/core/product/identifier/S1092852921000018/type/journal_article
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PublicationCentury 2000
PublicationDate 2022-06-01
PublicationDateYYYYMMDD 2022-06-01
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  year: 2022
  text: 2022-06-01
  day: 01
PublicationDecade 2020
PublicationPlace New York, USA
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PublicationTitle CNS spectrums
PublicationTitleAlternate CNS Spectr
PublicationYear 2022
Publisher Cambridge University Press
Publisher_xml – name: Cambridge University Press
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SubjectTerms Bipolar disorder
Case reports
Circadian rhythm
Emotional disorders
Humans
Hypotheses
Insomnia
Mood Disorders
Neurodegeneration
Neurotoxicity
Oxidative stress
Physiology
Proteins
Public health
Review
Sleep - physiology
Sleep deprivation
Sleep Initiation and Maintenance Disorders
Sleep Wake Disorders
Suicides & suicide attempts
Systematic review
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Title Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review
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https://www.ncbi.nlm.nih.gov/pubmed/33427150
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Volume 27
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