Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity

Abstract Background  Galectins have numerous cellular functions in immunity and inflammation. Short-term galectin-2 (Gal-2) blockade in ischemia-induced arteriogenesis shifts macrophages to an anti-inflammatory phenotype and improves perfusion. Gal-2 may also affect other macrophage-related cardiova...

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Bibliographic Details

Published in:	Thrombosis and haemostasis Vol. 122; no. 6; pp. 1047 - 1057
Main Authors:	Kane, Jamie, Jansen, Matthijs, Hendrix, Sebastian, Bosmans, Laura A., Beckers, Linda, Tiel, Claudia van, Gijbels, Marion, Zelcer, Noam, Vries, Carlie J. de, von Hundelshausen, Philipp, Vervloet, Marc, Eringa, Ed, Horrevoets, Anton J., Royen, Niels van, Lutgens, Esther
Format:	Journal Article
Language:	English
Published:	Rüdigerstraße 14, 70469 Stuttgart, Germany Georg Thieme Verlag KG 01.06.2022
Subjects:	Atherosclerosis and Ischaemic Disease atherosclerosis macrophages anti-inflammatory agents nanobodies galectin-2
ISSN:	0340-6245, 2567-689X, 2567-689X
Online Access:	Get full text
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