Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor

Because serine proteases, such as coagulation and/or fibrinolysis factors, may convert C5 into C5a and C5b, we investigated the effect of C5 in the presence of factor VIIa, factor Xa, factor IIa, or plasmin on the degranulation of hsMCs. [...]C3 induced a slight degranulation of hsMCs even in the pr...

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Veröffentlicht in:	Journal of allergy and clinical immunology Jg. 147; H. 3; S. 1101 - 1104.e7
Hauptverfasser:	Yanase, Yuhki, Matsuo, Yoshimi, Takahagi, Shunsuke, Kawaguchi, Tomoko, Uchida, Kazue, Ishii, Kaori, Tanaka, Akio, Matsubara, Daiki, Ozawa, Koichiro, Hide, Michihiro
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.03.2021 Elsevier Limited
Schlagworte:	Cell activation Coagulation factor VIIa Coagulation factors Complement activation Complement component C3 Complement component C5a Degranulation Fibrinolysis Histamine Leukocytes (basophilic) Plasmin Proteinase inhibitors Serine Serine proteinase Skin Stem cells Urticaria United Kingdom > UK Japan
ISSN:	0091-6749, 1097-6825, 1097-6825
Online-Zugang:	Volltext
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